C.15. Can the shift of the oxygen-hemoglobin dissociation curve be quantified?
Answer:
Yes, the shift of the oxygen-hemoglobin dissociation curve is quantified by means of the P50 value (the oxygen tension at which hemoglobin is 50% saturated). The normal P50 value of blood is 27 mm Hg. Decreased levels of 2,3-diphosphoglycerate (normal 4.8 mmol/mL of erythrocytes) cause a leftward shift of the curve, lowering the P50 value and reducing oxygen unloading at the tissues.
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