Associated anomalies occur 30 times more frequently in the patient with an isolated cleft palate than in the noncleft population. The most common nonsyndromic abnormalities are umbilical hernias, clubfoot, limb, and ear deformities. The most common syndromes associated with cleft lip and cleft palate are:

• Velocardiofacial (Shprintzen) syndrome

• van der Woude syndrome

• Stickler syndrome

• Pierre Robin syndrome (PRS)

• Fetal alcohol syndrome

• Goldenhar syndrome (facio-auriculo-vertebral syndrome or hemifacial microsomia)

• Treacher Collins syndrome

• Nager syndrome

• Down syndrome

References

• Calzolari E, Pierini A, Astolfi G, et al. Associated anomalies in multi-malformed infants with cleft lip and palate: an epidemiologic study of nearly 6 million births in 23 EUROCRAT registries. Am J Med Genet A. 2007;143A:528-537.