OBJECT DRUGS

• Valproic Acid (Depakene, etc.)

PRECIPITANT DRUGS

Carbapenem Antibiotics:

• Doripenem (Doribax)
• Ertapenem (Ivanz)
• Imipenem (Primaxin)
• Meropenem (Merrem)

Comment:

The administration of carbapenem antibiotics has been noted to markedly reduce the plasma concentrations of valproic acid. Reduction in seizure control may occur.

Class 3: Assess Risk & Take Action if Necessary

• Consider Alternative: If possible, consider an alternative antibiotic to a carbapenem in patients taking valproic acid.
• Monitor: Monitor for altered valproic acid plasma concentrations and response if a carbapenem antibiotic is initiated, discontinued, or changed in dosage.