Adult Dosing

Ocular surface anesthesia during ophthalmologic procedures

• Apply 2 gtt to the ocular surface in the area of the planned procedure; may repeat PRN

Pediatric Dosing

Ocular surface anesthesia during ophthalmologic procedures

• Apply 2 gtt to the ocular surface in the area of the planned procedure; may repeat PRN

[Outline]

• Adult Dosing
• Pediatric Dosing

• Indicated for ocular surface anesthesia during ophthalmologic procedures

• Hypersensitivity to any of the ingredients of the product
• Hypersensitivity to local anesthetics of the amide type

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Not for injection; only for ophthalmic use
• Increased incidence of permanent corneal opacification and ulceration with accompanying visual loss may occur on prolonged use

Pregnancy Category:B

Breastfeeding: Concentrations of lidocaine is very low in breast milk, and it is poorly absorbed by the infant. No special precautions are required because it is unlikely to cause any adverse effects in breastfed infants. This information is based on LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 28 April 2011). As per manufacturer's data, caution should be exercised when administered to nursing mothers.

• EENT: Conjunctival hyperemia, corneal epithelial changes, ocular burning upon instillation, corneal opacification, corneal ulcer, loss of vision
• CNS: Headache

• Local anesthetic agent; stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses which produces local anesthetic action
• Metabolized in the liver; CYP450: 1A2, 3A4; active metabolites: monoethylglycinexylidide and glycinexylidide
• Onset of action occurs between 20 seconds-1 minute and persists for 5-30 minutes
• Renally excreted (<10% unchanged) and (90% as metabolites)
• Half-life: Unknown

US Trade Name(s)

• Akten

US Availability

Akten

• OPTH GEL: 3.5%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Ophthalmic

Ophthalmic Anesthetics

Amide-type Local Anesthetics

Anesthesia

Ophthalmic Anesthetics

Amide-type Local Anesthetics