Adult Dosing
Management of pain
- 10 mg PO q12 hours
- May increase dose in increments of 10 mg PO q12hrs every 3-7 days as needed to achieve adequate analgesia
Note:
- Refer to package insert for conversion factors to Zohydro ER
Symptomatic relief of cough (Hycodan)
- 5 mg PO every 4-6 hours as needed, not to exceed three (5 mg) tablets or three teaspoonfuls of liquid in 24 hours.
Pediatric Dosing
Children 6 to 12 years of age for Symptomatic relief of cough (Hycodan)
- 2.5 mg (1/2 tablet or 1/2 teaspoonful) PO every 4-6 hours as needed, not to exceed three (5 mg) tablets or three teaspoonfuls of liquid in 24 hours.
- Safety and efficacy in pediatric patients have not been established, for other uses
[Outline]
Pregnancy Category:C
Breastfeeding: Maternal use of maximum dosages of oral narcotics while breastfeeding can cause infant drowsiness, particularly newborns are sensitive to even small dosages of narcotic analgesics, in the first week of life, however small volumes of colostrum is secreted in the first 2 to 3 days postpartum hence newborn's dosage is limited. Once the mother's milk comes in, it is best to avoid oral hydrocodone (and combinations) and administer nonnarcotic analgesic if necessary. Maximum recommended dosage is 30 mg/day. Monitor the infant for drowsiness, adequate weight gain, and developmental milestones, immediately contact the physician if baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 1 November 2013). Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from chlorpheniramine/hydrocodone, manufacturer recommends decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
