Adult Dosing
Uncomplicated urinary tract infections
- 100 mg PO bid x 10 days
- Alt: 200 mg PO qd x 10 days
Pneumocystis jiroveci pneumonia [Not FDA Approved]
- 5 mg/kg PO tid x 21 days in combination with dapsone 100 mg qd x 21 days
Prophylaxis of chronic urinary tract infections [Not FDA Approved]
Pediatric Dosing
Acute otitis media
Primsol
- Infants and children
6 months - 5 kg, 11 lb
- 1/2 tsp or 2.5 mL [25 mg] PO q12 hrs x 10 days
- 10 kg, 22 lb
- 1 tsp or 5 mL [50 mg] PO q12 hrs x 10 days
- 15 kg, 33 lb
- 1 and half tsp or 7.5 mL [75 mg] PO q12 hrs x 10 days
- 20 kg, 44 lb
- 2 tsp or 10 mL [100 mg] PO q12 hrs x 10 days
- 25 kg, 55 lb
- 2 and half tsp or 12.5 mL [125 mg] PO q12 hrs x 10 days
- 30 kg, 66 lb
- 3 tsp or 15 mL [150 mg] PO q12 hrs x 10 days
- 35 kg, 77 lb
- 3 and half tsp or 17.5 mL [175 mg] PO q12 hrs x 10 days
- 40kg, 88 lb
- 4 tsp or 20 mL [200 mg] PO q12 hrs x 10 days
- Notes:
- Safety is not established in pediatric patients <2 months of age
- Effectiveness is not established in the treatment of acute otitis media in patients <6 months of age
Uncomplicated urinary tract infections [Not FDA Approved]
- >12 yrs
- 100 mg (10 mL) PO bid x 10 days
- Alt: 200 mg (20 mL) PO qd x 10 days
Prophylaxis of chronic urinary tract infections [Not FDA Approved]
Pneumocystis jiroveci pneumonia [Not FDA approved]
- 5 mg/kg PO tid x 21 days in combination with dapsone 100 mg qd x 21 days
[Outline]
Renal Dose Adjustment (Based on CrCl)
- 15-30 mL/min: 50 mg PO bid
- <15 mL/min: Not recommended
Hepatic Dose Adjustment
- Hepatic impairment: Dose adjustments not defined; use with caution
See Supplemental Patient Information
- Rare cases of serious hypersensitivity reactions have been reported in patients treated with trimethoprim
- Large doses or prolonged administration of trimethoprim may interfere with hematopoiesis
- Monitor patients for symptoms of sore throat, fever, pallor, or purpura, which may indicate development of serious blood disorders. Perform CBC promptly if any of these symptoms occur and discontinue therapy if a marked reduction in the blood count is observed
- Clostridium difficile associated diarrhea (CDAD), ranging in severity from mild diarrhea to fatal colitis, has been reported with trimethoprim use
- Investigate all cases of diarrhea for presence of C. difficile. If CDAC is confirmed, discontinue the drug and initiate fluid and electrolyte management, protein supplementation, and antibiotic treatment of C. difficile
- Use of trimethoprim for prophylaxis or in the absence of a proven or strongly suspected bacterial infection is not recommended, as it may lead to development of drug-resistant bacteria
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- Folate deficiency
- Bone marrow depression
- Elderly patients
Supplemental Patient Information
- Instruct patients that the drug should only be used to treat bacterial infections and not viral infections
- Advise patients to immediately contact their physician on development of watery and bloody stools
Pregnancy Category:C
Breastfeeding: Low levels of trimethoprim are excreted in human milk which is not likely to cause any adverse effects in breastfed infants. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 5 July 2011). Manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Trimethoprim 100 MG TABS [Bottle] (WATSON LABS)
30 mg = $20.99
90 mg = $40.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
