Adult Dosing
Duodenal ulcer, active
- 800 mg PO qhs x 4-6 wks
- Alt: 400 mg PO bid or 300 mg PO qid
- Max: 1600 mg/day
Duodenal ulcer, maintenance
Active bening gastric ulcer
- 800 mg PO qhs x 6 wks
- Alt: 300 mg PO q6-8 hrs (with meals and at bedtime) x 6 wks
- Max: 2400 mg/day
GERD
- 1600 mg/day PO divided bid-qid x 12 wks
- Some patients may require chronic therapy
Pathological hypersecretory conditions
- 300-600 mg PO qid (with meals and at bedtime)
- Max: 2400 mg/day
Heartburn; prevention and treatment (OTC use only)
- 200 mg PO PRN. Max: 400 mg/day for up to 14 days
Pediatric Dosing
- Note: Safety and effectiveness in pediatric patients <16 yrs of age have not been established
Treatment of duodenal and gastric ulcers, GERD, hypersecretory states [Not FDA approved]
Child (Not FDA approved)
- 20-40 mg/kg/day PO divided q6-12 hrs
[Outline]
- Rare cases of anaphylaxis as well as rare episodes of hypersensitivity have been reported
- Rare instances of cardiac arrhythmias and hypotension have been reported following rapid IV administration
- Reversible CNS effects including mental confusion, psychosis, depression, agitation, anxiety, hallucinations, and disorientation have occurred
- Reversible confusional states have occurred in critically ill patients; patients
50 yrs and those with pre-existing hepatic and/or renal impairment are at an increased risk - Symptomatic relief with cimetidine does not preclude gastric malignancy
- It may cause nausea, dizziness, drowsiness, headache and diarrhea
Cautions: Use cautiously in
- Renal impairment (refer dose adjustment section)
- Hepatic impairment (refer dose adjustment section)
- Chronic pulmonary disease
- Immunocompromised states
- Debilitated individuals
- Diabetes mellitus
- Elderly population
Pregnancy Category:B
Breastfeeding: This drug is compatible and considered safe with breastfeeding based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776). Limited information indicates that cimetidine is excreted in breastmilk in small amounts and would produce infant serum levels much less than those with direct dosages to the neonates. Due to the potential to cause hepatic enzyme inhibition, other drugs may be preferred. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 15 September 2010).
Pricing data from www.DrugStore.com in U.S.A.
- Cimetidine 400 MG TABS [Bottle] (TEVA PHARMACEUTICALS USA)
90 mg = $31.99
180 mg = $47.97 - Cimetidine 200 MG TABS [Bottle] (MYLAN)
30 mg = $18.99
90 mg = $29.97 - Cimetidine 300 MG TABS [Bottle] (TEVA PHARMACEUTICALS USA)
180 mg = $29.99
360 mg = $59.98 - Tagamet 300 MG TABS [Bottle] (GLAXO SMITH KLINE)
60 mg = $81.99
180 mg = $229.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
