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Pathophys and Cause ⬇

Cause:Genetic, autosomal dominant; or alcohol

Pathophys:Elevated VLDL; carbohydrate-induced, causes liver to make too much triglyceride

Epidemiology ⬆ ⬇

Associated with diabetes (70%), obesity, hyperuricemia; very common

Signs and Symptoms ⬆ ⬇

Sx:None until MI

Si:None until MI

Complications ⬆ ⬇

MIs

r/o other causes of increased triglyceride-including drugs (thiazides, BCPs, estrogens, ß-blockers, isotretinoin), burns and trauma, sepsis, SLE, MIs, glycogen storage diseases, obesity, alcohol

Lab and Xray ⬆ ⬇

Lab:Chem:Cholesterol increased or normal; total cholesterol/HDL ratio increased; triglycerides 150-1000 mg %; supranate clear; infranate cloudy; PHLA normal; lipoPEP shows increased pre-ß-lipoprotein

  • Uric acid increased
  • GTT abnormal (70%)

Treatment ⬆

Rx:

Lose weight; rx diabetes; avoid alcohol, estrogens; diet of cholesterol <300 mg qd; exercise

Nicotinic acid (Niacin) (Hypercholesterolemia)