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General Reference ⬇

(Nejm 2003;348:2543)

Pathophys and Cause ⬆ ⬇

Cause:Autosomal dominant, perhaps X-linked recessive

Pathophys:Autoantibodies to type IV collagen destroy basement membrane

Signs and Symptoms ⬆ ⬇

Sx:School-age onset of deafness and hereditary nephritis

Complications ⬆

Occasionally thrombocytopenia (Ann IM 1975;82:639)