Adult Dosing

Vulvovaginal candidiasis

• 1 tab (100,000 units) intravaginally qhs x 2 wks

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of vulvovaginal candidiasis (moniliasis)

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• If sensitization or irritation is reported during use, discontinue the treatment
• Warn the patient against interruption or discontinuation of medication even during menstruation and even though symptomatic relief occur within few days
• Adjunctive measures such as therapeutic douches are unnecessary and are not inadvisable during the therapy, but cleansing douches can be used by nonpregnant women, if desired, for esthetic purposes

Supplemental Patient Information

• Patient should be warned against the interruption or discontinuation of medication even during menstruation and even though symptomatic relief occur within few days

Pregnancy Category:A

Breastfeeding: No information exists on the milk excretion of nystatin, it is virtually unabsorbed orally therefore acceptable for use in nursing mothers; including topical application to the nipple. This data is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 2 June 2011).

• GU: Vulvovaginal irritation
• DERM: Stevens-Johnson syndrome
• MISC: Hypersensitivity reaction

• Antifungal agent; binds to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components
• Not absorbed from intact skin or mucous membrane

US Trade Name(s)

• Only generic available

US Availability

nystatin (generic)

• TABS: 100,000 U

Canadian Trade Name(s)

• Nyaderm Vag

Canadian Availability

nystatin (generic)

• CRE: 100,000 U/g

Nyaderm Vag

• CRE: 25000 U/g

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Nilstat

Australian Availability

Nilstat

• CRE: 100,000 U/5 g

[Outline]

Antimicrobials

Vaginal Agents; Anti-infectives

Infectious Disease

Vaginal Agents; Anti-infectives

Obstetrics/Gynecology

Vaginal Agents; Anti-infectives