Adult Dosing
Constipation
Constilac, Constulose, Cholac, Enulose, Generlac
- 15-30 mL PO qd, may increase to 60 mL PO qd
- Response is seen within 24-48 hrs
Kristalose
- 10-20 g PO qd; Max: 40 g/day
Portal-systemic encephalopathy
- Starting dose: 30-45 mL qhr, until laxative effect is seen
- Maintenance dose: 30-45 mL PO tid-qid, may adjust the dose to produce 2-3 soft stools/day
- Note: Continuous long-term therapy is indicated to lessen the severity and prevent the recurrence of portal-systemic encephalopathy
Pediatric Dosing
Portal-systemic encephalopathy
- Infants: 2.5-10 mL PO in divided doses, to produce 2-3 soft stools/day
- Older children or adolescents: 40-90 mL in divided doses, to produce 2-3 soft stools/day
- Note: If initial dose causes diarrhea immediately reduce the dose
[Outline]
See Supplemental Patient Information
- Patients treated with lactulose solution who may be required to undergo electrocautery procedures during proctoscopy or colonoscopy. Accumulation of H2 gas in significant concentration in the presence of an electrical spark may result in an explosive reaction, hence patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution
- As lactulose solution contains galactose and lactose, use cautiously in diabetic patients
- In portal-systemic encephalopathy there is serious underlying liver disease with complications such as electrolyte disturbance, hence in overall management consider other specific therapy to treat liver diseases and electrolyte imbalance
- Administration of lactulose in infants causes hyponatremia and dehydration
- Monitor serum electrolytes level in patients who receive lactulose for more than six months
Cautions: Use cautiously in
Supplemental Patient Information
- Advise patients to report diarrhea, as dose may need adjustment
Pregnancy Category:B
Breastfeeding: Safety unknown; manufacturer advises caution.
US Trade Name(s)
- Constilac
- Constulose
- Cholac
- Enulose
- Generlac
- Kristalose
US Availability
lactulose (generic)
- SOLN: 10 g/15 mL
- SOLN: 10 g/packet
- SOLN: 20 g/packet
Constilac, Constulose, Cholac, Enulose, Generlac
Kristalose
Canadian Trade Name(s)
Canadian Availability
lactulose (generic)
Euro Lac
UK Trade Name(s)
UK Availability
lactulose (generic)
- SOLN: 67% w/v
- SOLN: 66.6% w/v
- SOLN: 3.4 g/5 mL
Duphalac
Lactugal
Australian Trade Name(s)
Australian Availability
lactulose (generic)
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Kristalose 10 GM PACK [Box] (CUMBERLAND PHARMACEUTICALS)
30 gm = $55.99
90 gm = $149.97 - Kristalose 20 GM PACK [Box] (CUMBERLAND PHARMACEUTICALS)
30 gm = $86.25
90 gm = $240.95
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.