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Interacting Drugs

OBJECT DRUGS

Antiarrhythmics (CYP3A4 Substrates):

PRECIPITANT DRUGS

Enzyme Inducers:


Comment:

CYP3A4 is quite sensitive to enzyme induction, and enzyme inducers have been shown to reduce plasma concentrations of amiodarone, disopyramide, dronedarone, and quinidine. Depending on the potency of the enzyme inducer, the reductions in antiarrhythmic plasma concentrations may result in substantial reductions in antiarrhythmic effects.


Class 3: Assess Risk & Take Action if Necessary