Adult Dosing
Hypertension
Capsules
- Initial 12.5 mg/day PO
- Max: 50 mg/day PO
Tablets
- Initial 25 mg/day PO
- Max: 50 mg/day PO
Peripheral edema
Tablets
- Initial 25-100 mg/day PO x 1 or divided bid on alternate days or on three to five days each week
Pediatric Dosing
Hypertension
Tablets
- Child <6 months: up to 3mg/kg/day PO divided bid
- 6 months-12 yrs: 1-3 mg/kg/day PO x 1 or divided bid; Max: 37.5 mg/day PO
- 2-12 yrs: 1-3 mg/kg/day PO x 1 or divided bid; Max: 100 mg/day PO
Note: Safety and effectiveness of hydrochlorothiazide capsules in pediatric patients have not been established
[Outline]
- Therapy may precipitate azotemia in patients with renal disease. Therefore use with caution in severe renal disease. Cumulative effects of the drug may develop in patients with impaired renal function
- Use with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma
- Use with caution in patients with or without a history of allergy or bronchial asthma to avoid sensitivity reactions
- Avoid concomitant lithium use
- Therapy may cause exacerbation or activation of systemic lupus erythematosus
- Carefully monitor fluid or electrolyte imbalance during therapy
- Therapy associated hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements such as foods with a high potassium content
- Carefully adjust dosage of insulin or oral hypoglycemic agents when administering hydrochlorothiazide in diabetic patients
- May increase the urinary excretion of magnesium; this may result in hypomagnesemia
- Suspend therapy before carrying out tests for parathyroid function because marked hypercalcemia may be evidence of hidden hyperparathyroidism
- Therapy may cause increases in cholesterol and triglyceride levels
- Therapy may cause can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma
Cautions: Use cautiously in
- Severe renal impairment
- Hepatic impairment
- Progressive hepatic disease
- Electrolyte abnormalities
- Volume depletion
- Arrhythmias
- Post-sympathectomy
- Diabetes mellitus
- Seizure disorder
- Pregnancy near term
- Gestational HTN
- SLE
- Hx of gout
- Hx of pancreatitis
- Elderly patients
Microzide, Oretic interacts with :
Pregnancy Category:B
Breastfeeding: Safe. Hydrochlorothiazide doses of 50 mg daily or less are acceptable during lactation. Intense diuresis with large doses may decrease breastmilk production. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 9 March 2011). Maternal medication usually compatible with breastfeeding, no observable change was seen in the nursing infant while the mother was ingesting the compound. This information is based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776/T6 last accessed 9 March 2011). Due to the potential for serious adverse reactions in nursing infants, manufacturer recommends discontinuation of nursing or discontinuation of drug, taking into account the importance of the drug to the mother.
US Trade Name(s)
US Availability
hydrochlorothiazide (generic)
- CAPS: 12.5 mg
- TABS: 12.5, 25, 50 mg
Microzide
Oretic
Canadian Trade Name(s)
Canadian Availability
hydrochlorothiazide (generic)
Apo-Hydro
- TABS: 12.5, 50, 100, 250 mg
Nu-Hydro
Urozide
UK Trade Name(s)
UK Availability
Australian Trade Name(s)
Australian Availability
Dithiazide
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Hydrochlorothiazide 12.5 MG TABS [Bottle] (ACTAVIS ELIZABETH)
100 mg = $27.99
200 mg = $43.97 - Hydrochlorothiazide 50 MG TABS [Bottle] (IVAX PHARMACEUTICALS)
INC. mg = $100
mg = $200 - Hydrochlorothiazide 12.5 MG CAPS [Bottle] (WATSON LABS)
30 mg = $14.99
60 mg = $22.98 - Microzide 12.5 MG CAPS [Bottle] (WATSON LABS)
30 mg = $42.02
90 mg = $107.51 - Hydrochlorothiazide 25 MG TABS [Bottle] (QUALITEST)
100 mg = $12.99
200 mg = $15.96
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
