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Pathophys and Cause

Cause:Often mixed organisms with anaerobic bacteria (Anaerobic Infections (Except Clostridial) such as fusobacterium, bacteroides, peptostreptococcus, and peptococcus as well as aerobic organisms such as necrotizing gram-negative rods and staph; from aspiration of mouth organisms

Epidemiology

Associated w alcoholism, loss of consciousness, recent dental work

Signs and Symptoms

Sx:Fever, sputum, weight loss

Complications

Empyema, bronchopleural fistula, brain abscess

Lab and Xray

Xray:Chest shows abscess cavities with air fluid levels; or may show a round “pneumonia” before the abscess communicates with a bronchus to create an air fluid level; r/o bronchopleural fistula or empyema from which it may be very hard to tell

Treatment

Rx:

Clindamycin 600-900 mg iv q8h until improves, then 300 mg po q6h; or ampicillin/sulbactam (Unasyn)

Bronchoscopy if doesn’t resolve