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Signs and Symptoms ⬇

Si:On mucosal surfaces

Complications ⬆ ⬇

Oral squamous cell cancers

Lab and Xray ⬆ ⬇

Lab: Path:Biopsy shows nuclei and plasma cells in stratum corneum

Treatment ⬆

Rx:13-cis-retinoic acid 1-2 mg/kg qd (Nejm 1986;315:1501); resection does not diminish the 25% oral carcinoma rate (Nejm 2002;350:1405)