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General Reference ⬇

Ann IM 1985;102:705

Pathophys and Cause ⬆ ⬇

Cause:Calymmatobacterium granulomatis

Epidemiology ⬆ ⬇

Venereally spread, ie, an STD; highest rates in low-income areas

Signs and Symptoms ⬆ ⬇

Sx:Painless ulcer

Si:Genital papule, inguinal nodes. Skin breaks down into granulation tissue

Course ⬆ ⬇

Long term even with rx

Lab and Xray ⬆ ⬇

Lab:Path:Biopsy shows diagnostic intracellular organisms, called Donovan bodies

Treatment ⬆

Rx:1st tetracycline; 2nd streptomycin