| Clinical symptoms of DVT | No Yes |
| Other diagnosis less likely than PE | No Yes |
| Heart rate greater than 100 beats per minute | No Yes |
| Immobilization or surgery within past 4 weeks | No Yes |
| Previous DVT or PE | No Yes |
| Hemoptysis | No Yes |
| Malignancy | No Yes |
Adapted with permission from Wells PS, Anderson DR, Rodger M, Ginsberg JS, Kearon C, Gent M, et al. Derivation of a simple clinical model to categorize patients' probability of pulmonary embolism: increasing the model utility with the SimpliRED D-dimer. Thromb Haemost 2000;83:418.