OBJECT DRUGS

• Rivaroxaban (Xarelto)

PRECIPITANT DRUGS

Enzyme Inhibitors:

• Amiodarone (Cordarone, etc.)
• Amprenavir (Agenerase)
• Aprepitant (Emend)
• Atazanavir (Reyataz)
• Conivaptan (Vaprisol)
• Cyclosporine (Neoral, etc.)
• Danazol (Danocrine)
• Darunavir (Prezista)
• Delavirdine (Rescriptor)
• Dronedarone (Multaq)
• Indinavir (Crixivan)
• Nefazodone
• Nelfinavir (Viracept)
• Ritonavir (Norvir)
• Saquinavir (Invirase)
• Tamoxifen (Nolvadex)
• Telaprevir (Incivek)

Comment:

Inhibitors of CYP3A4 or P-glycoprotein may increase the concentration of rivaroxaban. Precipitant drugs that inhibit both CYP3A4 and P-glycoprotein may produce a larger increase in rivaroxaban concentrations.

Class 3: Assess Risk & Take Action if Necessary

• Monitor: Monitor for altered rivaroxaban effect if one of these inhibitors is initiated, discontinued or changed in dosage; adjustments of rivaroxaban dosage may be needed. If rivaroxaban is initiated in the presence of therapy with one of these agents, consider initiating therapy with conservative doses of rivaroxaban.