Adult Dosing

Psychiatric and emotional emergencies

• 50-100 mg IM stat and q4-6 hrs PRN

Nausea and vomiting

• 25-100 mg IM

Pre- and postoperative and pre- and postpartum adjunctive medication

• 25-100 mg IM

Pediatric Dosing

Nausea and vomiting

• 0.5 mg/lb body weight IM

Pre- and postoperative adjunctive medication

• 0.5 mg/lb body weight IM

[Outline]

• Adult Dosing
• Pediatric Dosing

• Psychiatric and emotional emergencies
• Nausea and vomiting
• Pre- and postoperative and pre- and postpartum adjunctive medication

• Hypersensitivity to any of the ingredients of the product
• SC, IV, or intra-arterial administration
• Pregnancy 1st trimester

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Use with caution when administering with other CNS depressants. Reduce dosage of CNS depressants
• Caution should be exercised while driving a car or operating dangerous machinery because drowsiness may occur with use of the drug
• Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased
• Start therapy with small dosage to avoid hepatic, renal or cardiac dysfunction
• Use with caution in elderly patients as they are more likely to have decreased renal function, care should be taken in dose selections

Cautions: Use cautiously in

• Renal impairment
• Elderly patients
• Asthma

Pregnancy Category:C

Breastfeeding: Safety unknown. Small occasional doses of hydroxyzine would not be expected to cause any adverse effects in breastfed infants. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 10 March 2011). According to manufacturer data, hydroxyzine should not be given to nursing mothers.

• CNS: Seizures, drowsiness, agitation, ataxia, dizziness, headache, weakness
• RESP: Wheezing, dyspnea
• GI: Dry mouth, bitter taste, constipation, nausea
• GU: Urinary retention
• DERM: Flushing
• MISC: Chest tightness, slurred speech

• Antianxiety, antihistaminic, sedative/hypnotics; acts as a CNS depressant at the subcortical level of the CNS; has anticholinergic, antihistaminic, and antiemetic properties, blocks histamine 1 receptors
• Well absorbed following IM administration
• Extensively metabolized by the liver
• Excreted in feces, bile
• Half-life: 3 hrs

US Trade Name(s)

• Only generic available

US Availability

hydroxyzine (generic)

• INJ: 25 mg/mL (1 mL vial)
• INJ: 50 mg/mL (1, 2, 10 mL vial)

Canadian Trade Name(s)

• Only generic available

Canadian Availability

hydroxyzine (generic)

• INJ: 50 mg/mL (1 mL vial)

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Gastrointestinal

Antiemetics

Miscellaneous Agents

Psychiatric

Anxiolytics/Sedatives/Hypnotics

Miscellaneous Agents

Neurologic

Anxiolytics/Sedatives/Hypnotics

Miscellaneous Agents