Adult Dosing
Non-nodular moderate to severe acne vulgaris [Solodyn, Ximino]
Usual dosage [Minocin]
- Initial dose: 200 mg PO, followed by 100 mg PO bid
- Alt: 100-200 mg PO, followed by 50 mg PO qid
Uncomplicated gonococcal infections other than urethritis and anorectal infections in men
- Initial dose: 200 mg PO, followed by 100 mg PO bid x 4 days
- Perform culture within 2-3 days post therapy
Uncomplicated gonococcal urethritis in men, meningococcal carrier state
Syphilis
- 100 mg PO bid x 10-15 days
Mycobacterium marinum infections
Uncomplicated urethral, endocervical, or rectal infection in adults
Note:
- Administer the drug with adequate amounts of fluids to reduce the risk of esophageal irritation and ulceration
- To be taken with or without food
Pediatric Dosing
Note:- Not recommended in children 8 years or age and younger due to potential for tooth discoloration
Non-nodular moderate to severe acne vulgaris [Solodyn, Ximino]
- Children >12 yrs: 1 mg/kg daily x 12 wks
Usual dosage (>8 yrs)
- Initial dose: 4 mg/kg PO, followed by 2 mg/kg PO bid
- Max: 100 mg
Note:
- Administer the drug with adequate amounts of fluids to reduce the risk of esophageal irritation and ulceration
- To be taken with or without food
[Outline]
See Supplemental Patient Information
- Minocycline can cause fetal harm when administered to pregnant women. If tetracycline is used in pregnant women or if the patient becomes pregnant while taking the treatment, the patient should be appraised of the potential hazard to the fetus
- Minocycline can cause permanent discoloration of teeth and enamel hypoplasia, hence should not be used during tooth development (last half of pregnancy, infancy, <8 yrs)
- Reversible decrease in the fibula growth rate has been observed in premature human infants, given oral tetracycline, as tetracyclines form a stable calcium complex in any bone-forming tissue
- Fatal cases of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) have been reported with minocycline use. Immediately discontinue the drug if this syndrome occurs
- Higher serum levels of tetracycline may lead to azotemia, hyperphosphatemia, and acidosis, in patients with significantly impaired renal function. Monitor creatinine and BUN periodically and do not exceed the total daily dose of 200 mg/day
- If renal impairment exists, even usual oral or parenteral doses can lead to systemic accumulation of the drug and possible liver toxic
- Minocycline can cause photosensitivity manifested by an exaggerated sunburn reaction
- Patients should be cautioned about driving vehicles or using hazardous machinery while on minocycline therapy, as it can cause CNS symptoms like light-headedness, dizziness, or vertigo. These symptoms usually disappears after discontinuation of the treatment
- Clostridium difficile associated diarrhea (CDAD) ranging from mild diarrhea to fatal colitis occurs with minocycline therapy as antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile
- C. difficile produces toxins A and B which contribute to CDAD. Hypertoxin producing strains causes increased morbidity and mortality since these infections can be refractory to antibiotic therapy and may require colectomy. Careful medical examination is necessary since CDAD may occur >2 months after administration of drug
- If CDAD is suspected/confirmed discontinue the treatment, provide fluid, electrolyte, and protein supplementation along with antibiotics for C. difficile, surgical evaluation as clinically needed
- Minocycline can result in overgrowth of non-susceptible organisms, including fungi, discontinue the drug if superinfection occurs and institute appropriate therapy
- Prescribing antibiotics in the absence of proven or strongly suspected bacterial infection increases the risk of development of drug-resistant bacteria
- Pseudotumor cerebri (benign intracranial hypertension) manifestations as headache and blurred vision, bulging fortanels in infants has been observed with the use of tetracyclines
- Hepatotoxicity including fulminant hepatic failure has been reported with minocycline, use cautiously in patients with hepatic dysfunction and in conjunction with other hepatotoxic drugs
- Drug-induced lupus-like syndrome, autoimmune hepatitis, vasculitis and serum sickness manifested by fever, rash, arthralgia, and malaise have been reported with long-term use of minocycline. Discontinue the drug immediately and perform liver function tests, ANA, CBC, and other appropriate tests if autoimmune syndromes suspected
- Concomitant use of isotretinoin is not recommended due to additive risk of pseudotumor cerebri
Caution: Use cautiously in
- Renal impairment
- Hepatic impairment
- Concomitant use of hepatotoxic drug
- SLE
Supplemental Patient Information
- Patients should be cautioned about driving vehicles or using hazardous machinery while on minocycline therapy, as it can cause CNS symptoms like light-headedness, dizziness, or vertigo
Dynacin, Minocin, Solodyn, Ximino interacts with :
Pregnancy Category:D
Breastfeeding: Because of possible staining of infants' dental enamel or bone deposition of tetracyclines, many reviews state that tetracyclines are contraindicated during breastfeeding. However Short-term use of minocycline is acceptable in nursing mothers as short-term use of minocycline is not likely to harm during lactation because milk levels are low and absorption by the infant is inhibited by the calcium in breastmilk. Avoid prolonged or repeat courses during nursing. Monitor the infant for rash and for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). Black discoloration of breastmilk has been reported with minocycline. This data is based on upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 5 March 2011). Because of the potential for serious adverse reactions in nursing infants from the tetracyclines, manufacturer recommends that a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
US Trade Name(s)
- Dynacin
- Minocin
- Solodyn
- Ximino
US Availability
minocycline (generic)
- CAPS: 50, 75, 100 mg
- TABS: 50, 75, 100 mg
- ETABS: 45, 90, 135 mg
Dynacin
Minocin
Solodyn
- ETABS: 55, 65, 80, 105, 115 mg
Ximino
- ECAPS: 45, 67.5, 90, 112.5, 135 mg
Canadian Trade Name(s)
Canadian Availability
minocycline (generic)
Minocin
UK Trade Name(s)
- Acnamino MR
- Aknemin
- Minocin
- Sebact MR
- Sebomin MR
UK Availability
minocycline (generic)
Acnamino MR, Minocin, Sebact MR, Sebomin MR
Aknemin
Australian Trade Name(s)
Australian Availability
Akamin, Minomycin
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Dynacin 75 MG TABS [Bottle] (MEDICIS)
30 mg = $365.98
90 mg = $1050.02 - Minocin 50 MG CAPS [Bottle] (TRIAX PHARMACEUTICALS)
30 mg = $139.99
90 mg = $389.95 - Solodyn 65 MG TB24 [Bottle] (MEDICIS)
30 mg = $848.03
90 mg = $2457.84 - Minocin 100 MG CAPS [Bottle] (TRIAX PHARMACEUTICALS)
30 mg = $321.98
90 mg = $920.98 - Dynacin 75 MG CAPS [Bottle] (MEDICIS)
30 mg = $195.99
90 mg = $524.95 - Dynacin 100 MG TABS [Bottle] (MEDICIS)
30 mg = $440.01
90 mg = $1240.01 - Solodyn 45 MG TB24 [Bottle] (MEDICIS)
30 mg = $799.24
90 mg = $2313.4 - Solodyn 135 MG TB24 [Bottle] (MEDICIS)
30 mg = $799.24
90 mg = $2313.4 - Solodyn 80 MG TB24 [Bottle] (MEDICIS)
30 mg = $831.97
90 mg = $2411.99 - Solodyn 55 MG TB24 [Bottle] (MEDICIS)
30 mg = $826.96
90 mg = $2394.9 - Minocycline HCl 50 MG TABS [Bottle] (RANBAXY PHARMACEUTICALS)
30 mg = $102.99
90 mg = $279.97 - Solodyn 90 MG TB24 [Bottle] (MEDICIS)
100 mg = $2698.59
300 mg = $7653.9 - Solodyn 115 MG TB24 [Bottle] (MEDICIS)
30 mg = $816
90 mg = $2409.92 - Dynacin 50 MG TABS [Bottle] (MEDICIS)
30 mg = $249.99
90 mg = $720
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
12 years [Solodyn, Ximino]