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Interacting Drugs

OBJECT DRUGS

Immunosuppressants:

PRECIPITANT DRUGS

Enzyme Inducers:


Comment:

Enzyme inducers have been reported to enhance the metabolism of these immunosuppressants. This effect is probably due to induction of CYP3A4 and P-glycoprotein (PGP). Preliminary evidence suggests that levothyroxine acts as a PGP inducer in the small intestine; other thyroid hormones probably act similarly.


Class 2: Use Only if Benefit Felt to Outweigh Risk