OBJECT DRUGS
Immunosuppressants:
- Cyclosporine (Neoral, etc.)
- Sirolimus (Rapamune)
- Tacrolimus (Prograf, etc.)
PRECIPITANT DRUGS
Enzyme Inducers:
- Barbiturates
- Bosentan (Tracleer)
- Carbamazepine (Tegretol, etc.)
- Efavirenz (Sustiva)
- Levothyroxine (Synthroid, etc.)
- Nevirapine (Viramune, etc.)
- Oxcarbazepine (Trileptal, etc.)
- Phenytoin (Dilantin, etc.)
- Primidone (Mysoline)
- Rifabutin (Mycobutin)
- Rifampin (Rifadin, etc.)
- Rifapentine (Priftin)
- St. John's Wort
Comment:
Enzyme inducers have been reported to enhance the metabolism of these immunosuppressants. This effect is probably due to induction of CYP3A4 and P-glycoprotein (PGP). Preliminary evidence suggests that levothyroxine acts as a PGP inducer in the small intestine; other thyroid hormones probably act similarly.
Class 2: Use Only if Benefit Felt to Outweigh Risk
- Use Alternative: Use an alternative to the enzyme inducer if possible.
- Monitor: If an enzyme inducer is necessary, monitor for altered immunosuppressant effect if an enzyme inducer is initiated, discontinued, or changed in dosage; substantial dosage adjustments of immunosuppressants may be necessary. Keep in mind that enzyme induction is usually gradual and may take days to weeks for onset and offset, depending on the specific inducer.