Adult Dosing
Duodenal ulcers
- Recommended dose: 15 mg PO qd x 4 wks
- Maintenance dose: 15 mg PO qd
Benign gastric ulcer
- Recommended dose: 30 mg PO qd x upto 8 wks
NSAID-associated gastric ulcer
- Recommended dose: 30 mg PO qd x 8 wks
- To reduce risk of gastric ulcer: 15 mg PO qd x 12 wks
Gastroesophageal reflux disease (GERD)
- Symptomatic GERD
- Recommended dose: 15 mg PO qd x up to 8 wks
- Erosive esophagitis
- Recommended dose: 30 mg PO qd x up to 8 wks
- If recurrence or incomplete healing; repeat x 8 wks
Hypersecretory conditions including Zollinger-Ellison syndrome
- Recommended dose: 60 mg PO qd
- >120 mg/day in divided doses
- Max: 90 mg PO bid
Note Administer dose before meals. ODT should not be crushed, chewed and cut
Pediatric Dosing
Short-term treatment of symptomatic GERD and erosive esophagitis
- 1-11 yrs
30 kg- Recommended dose: 15 mg PO qd x up to 12 wks
- Max: 30 mg bid
- >30 kg
- Recommended dose: 30 mg PO qd x up to 12 wks
- Max: 30 mg bid
- 12-17 yrs
- Nonerosive GERD
- Recommended dose: 15 mg PO qd x up to 8 wks
- Erosive esophagitis
- Recommended dose: 30 mg PO qd x up to 8 wks
- Max: 30 mg bid
Maintenance of healing of erosive esophagitis
- Recommended dose: 15 mg PO qd
Hypersecretory conditions including Zollinger-Ellison syndrome
- Recommended dose: 60 mg PO qd
Note:
- Dose can be increased after 2 or more weeks of treatment
- Administer dose before meals
- ODT should not be crushed, chewed and cut
[Outline]
- Symptomatic response with lansoprazole does not preclude the presence of gastric malignancy
- PPI therapy including lansoprazole may increase risk of Clostridium difficile associated diarrhea, particularly in hospitalized patients
- Increased risk for osteoporosis-related fractures of the hip, wrist or spine have been associated with high dose or long-term proton pump inhibitor (PPI) therapy
- Hypomagnesemia has been reported with prolonged usage
- Use of PPIs with high dose methotrexate may increase and prolong serum levels of methotrexate and its metabolite leading to methotrexate toxicities. Temporary withdrawal of the PPI must be considered in patients who are on high-dose of methotrexate
Cautions : Use cautiously in
- Hepatic impairment
- Long term use
- High dose treatment
- Patients >50 yrs
- PKU (phenylalanine-containing forms)
- Hypomagnesemia
Pregnancy Category:B
Breastfeeding: Safety unknown. No information is available on the use of lansoprazole during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 14 April 2011). Manufacturer recommends discontinuing drug or nursing taking into consideration the importance of drug to the mother.
Pricing data from www.DrugStore.com in U.S.A.
- Prevacid 15 MG CPDR [Bottle] (TAKEDA PHARMACEUTICALS)
30 mg = $213.98
90 mg = $617.99 - Prevacid SoluTab 30 MG TBDP [Box] (TAKEDA PHARMACEUTICALS)
30 mg = $198.99
90 mg = $567.94 - Lansoprazole 30 MG CPDR [Bottle] (SANDOZ)
30 mg = $99.99
90 mg = $245.97 - Lansoprazole 15 MG TBDP [Box] (SANDOZ)
30 mg = $162.98
90 mg = $466.95 - Lansoprazole 30 MG TBDP [Box] (SANDOZ)
30 mg = $162.98
90 mg = $466.95 - Lansoprazole 15 MG CPDR [Bottle] (SANDOZ)
30 mg = $105.99
90 mg = $263.97 - Prevacid SoluTab 15 MG TBDP [Box] (TAKEDA PHARMACEUTICALS)
100 mg = $631.98
300 mg = $1850.93
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
