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Use and Dosing

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Notes

Primary or secondary gout

Mild gout

Moderately severe tophaceous gout

Flare-up of acute gouty attacks

Chemo-related hyperuricemia

Recurrent calcium oxalate calculi

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Chemo-related hyperuricemia

6-10 yrs

<6 yrs

>10 yrs


[Outline]

Indications

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment (Based on CrCl)

Hepatic Dose adjustment

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in

Supplemental Patient Information

Interactions

Lopurin, Zyloprim interacts with :

significance_1.gifAzasan
significance_1.gifAzathioprine
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significance_1.gifMercaptopurine
significance_1.gifPurinethol
significance_1.gifPurixan

Pregnancy/Breast Feeding

Pregnancy Category:C

Breastfeeding: This drug is compatible and considered safe with breastfeeding based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776. Allopurinol and its active metabolite oxypurinol are excreted in breast milk. Maternal doses of 300 mg/day provide near therapeutic dose and plasma levels in an exclusively breastfed infant. If allopurinol is required by the mother, it is not a reason to discontinue breastfeeding, but exclusively breastfed infants should be monitored including observation for allergic reactions (rash) and periodic CBC and differential blood counts. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 03 December 2010). Manufacturer advises caution

Adverse Reactions

Clinical Pharmacology

Brands and Availability

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US Trade Name(s)

US Availability

allopurinol (generic)

Lopurin

Zyloprim

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Canadian Trade Name(s)

Canadian Availability

allopurinol (generic)

Alloprin

Novopurol

Zyloprim

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UK Trade Name(s)

UK Availability

allopurinol (generic)

Zyloric

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Australian Trade Name(s)

Australian Availability

allopurinol (generic)

Allosig

Progout


[Outline]

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Classification

Rheumatologic

Anti-Gout Agents
Xanthine Oxidase Inhibitors

Allergy & Immunology

Anti-Gout Agents
Xanthine Oxidase Inhibitors

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill