Upper respiratory tract, genito-urinary tract, skin and soft tissue infections
- 250 mg IM/IV q6-8 hrs; can increase to 500 mg q6-8 hrs in severe infections
Lower respiratory tract infections
- 500 mg IM/IV q6-8 hrs
Bacterial septicemia
- 1,000 mg IV (as slow IV or IV infusion) q6 hrs
Endocarditis prophylaxis (Based on the recommendations of the British Society)
- Refer amoxicillin [Oral] monograph for prophylaxis by oral route
- Patient given general anesthetic
- Adults and Elderly: 1,000 mg amoxicillin IM immediately before induction; with 500 mg PO, 6 hours later
- Note: For patients undergoing extraction, scaling or surgery involving gingival tissues, and who have not received penicillin in the previous month
Endocarditis prophylaxis (Based on recommendations of the British Society)
- Patients for whom referral to hospital is recommended
- Adults and Elderly: Start 1,000 mg amoxicillin IM with 120 mg gentamicin IM, immediately prior to anesthesia (if given) or 15 minutes prior to dental procedure; followed by (6 hours later): 500 mg amoxicillin PO
- Note: For patients requiring GA given a penicillin in previous month; patients requiring GA having a prosthetic valve; patients with
1 attacks of endocarditis
Genito-urinary Surgery or Instrumentation
- Prophylaxis for patients who have no UTI and who are to have GU surgery or instrumentation under GA
- Adults and Elderly: Start 1,000 mg amoxicillin IM with 120 mg gentamicin IM, immediately before induction; followed by (6 hours later): 500 mg amoxicillin orally or IM as per clinical condition
Obstetric and Gynecological Procedures and Gastro-intestinal Procedures
- Routine prophylaxis is recommended only for patients with prosthetic valves
- Adults and Elderly: Start 1,000 mg amoxicillin IM with 120 mg gentamicin IM, immediately before induction; followed by (6 hours later): 500mg amoxicillin orally or IM as per clinical condition
Surgery or Instrumentation of the Upper Respiratory Tract
- Patients other than those with prosthetic valve
- Adults and Elderly: 1,000 mg amoxicillin IM immediately before induction; followed by 500 mg IV, 6 hours later
Surgery or Instrumentation of the Upper Respiratory Tract
- Patients with prosthetic heart valve
- Adults and Elderly: Start 1,000 mg amoxicillin IM with 120 mg gentamicin IM, immediately before induction; followed by (6 hours later):500mg Amoxil IM
- 2 gm amoxicillin IV q4 hr and gentamicin 1 mg/kg IV/IM every 8 hr for 4 to 6 weeks (see gentamicin monograph)
Upper respiratory tract, genito-urinary tract, skin and soft tissue infections
- Child (< 20 kgs): 20 mg/kg/day IV/IM in divided doses q6-8 hrs; can increase to 40 mg/kg/day in severe infections
Lower respiratory tract infections
- Child (< 20 kgs): 40 mg/kg/day IV/IM in divided doses q6-8 hrs
- Child: 150-200 mg/kg/day divided q3-4 hrs
Endocarditis prophylaxis (Based on recommendations of the British Society)
- Refer amoxicillin [Oral] monograph for prophylaxis by oral route
- Patient given general anesthesia
- Child: <10 yrs: Give 1/2 of the adult dose
- Note: For patients undergoing extraction, scaling or surgery involving gingival tissues, and who have not received penicillin in the previous month
Endocarditis prophylaxis (Based on the recommendations of the British Society)
- Patients for whom referral to hospital is recommended
- Child: <10 yrs: Give amoxicillin 1/2 of the adult dose; dose of gentamicin should be 2mg/kg
- Note: For patients requiring GA given a penicillin in previous month; patients requiring GA having a prosthetic valve; patients with 1 attacks of endocarditis
Genito-urinary Surgery or Instrumentation
- Prophylaxis for patients who have no UTI and who are to have GU surgery or instrumentation under GA
- Child: <10 yrs: Give amoxicillin 1/2 of the adult dose; gentamicin dose should be 2 mg/kg (see gentamicin monograph)
Obstetric and Gynecological Procedures and Gastro-intestinal Procedures
- Routine prophylaxis is recommended only for patients with prosthetic valves
- Child: <10 yrs: Give amoxicillin 1/2 of the adult dose; gentamicin dose should be 2 mg/kg (see gentamicin monograph)
Surgery or Instrumentation of the Upper Respiratory Tract
- Patients other than those with prosthetic valve
- Child: <10 yrs: Give 1/2 of the adult dose
Surgery or Instrumentation of the Upper Respiratory Tract
- Patients with prosthetic heart valve
- Child: <10 yrs: Give amoxicillin 1/2 of the adult dose; gentamicin dose should be 2mg/kg
- 300 mg/kg/day IV in 4-6 equally divided doses. Max: 12 gm/day. Use combination of streptomycin, imipenem/cilastatin or ceftriaxone based on microbiology of infection.
