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Pathophys and Cause

Cause:Human herpesvirus 6

Epidemiology

14% of febrile children under age 2 yr in ER have it; cause of 1/3 of febrile seizures under age 2 yr (Nejm 1994;331:432; 1992;326:1145)

Signs and Symptoms

Sx:High fever to 105°F (40.5°C) × 3-4 d, defervesce, then rash in 10%

Si:Viral exanthem, fever

Treatment

Rx:Symptomatic