OBJECT DRUGS

• Rivaroxaban (Xarelto)

PRECIPITANT DRUGS

Enzyme Inducers:

• Barbiturates
• Bosentan (Tracleer)
• Carbamazepine (Tegretol, etc.)
• Efavirenz (Sustiva)
• Nevirapine (Viramune, etc.)
• Oxcarbazepine (Trileptal, etc.)
• Phenytoin (Dilantin, etc.)
• Primidone (Mysoline)
• Rifabutin (Mycobutin)
• Rifampin (Rifadin, etc.)
• Rifapentine (Priftin)
• St. John's Wort

Comment:

Inducers of CYP3A4 or P-glycoprotein may reduce the concentration of rivaroxaban. Several days to weeks may be required to see the full effect an inducer on rivaroxaban. A reduction in the anticoagulant effect may occur.

Class 3: Assess Risk & Take Action if Necessary

Monitor: Monitor for altered rivaroxaban effect if a CYP3A4 or P-glycoprotein inducer is initiated, discontinued or changed in dosage; adjustments of rivaroxaban dosage may be needed.