The nurse is teaching a family with an infant diagnosed with thalassemia major about the disease. Which information would be most appropriate to include in the teaching?

1. This disease can be cured with deferoxamine (Desiferal)
2. Thalassemia major can be managed with blood transfusions and drug therapy
3. Many children with this disorder have no signs or symptoms
4. All children with this disease usually become profoundly mentally and physically retarded