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Use and Dosing

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Severe rheumatoid arthritis (methotrexate (generic), Otrexup)

Psoriasis (methotrexate (generic), Otrexup)

Trophoblastic neoplasms (choriocarcinoma, chorioadenoma destruens, hydatiform mole) (methotrexate (generic))

Leukemia (methotrexate (generic))

Meningeal leukemia (methotrexate (generic))

Osteosarcoma (methotrexate (generic))

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Leukemia

Meningeal leukemia

Juvenile rheumatoid arthritis

2-16 yrs


[Outline]

Indications

Neoplastic diseases (methotrexate (generic))

Psoriasis (methotrexate (generic), Otrexup)

Rheumatoid arthritis (methotrexate (generic), Otrexup)

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment (Based on CrCl)

Hepatic Dose Adjustment

RA/psoriasis

Other indications

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in

Supplemental Patient Information

Interactions

Otrexup interacts with :

significance_2.gifAciphex
significance_2.gifAcular
significance_2.gifAcular LS
significance_2.gifAcuvail
significance_2.gifAdvil
significance_2.gifAdvil liqui-gels
significance_2.gifAdvil migraine liqui-gels
significance_2.gifAleve
significance_2.gifAmoxicillin
significance_2.gifAmoxil
significance_2.gifAnaprox
significance_2.gifAnaprox DS
significance_2.gifAnsaid
significance_2.gifBactocill
significance_2.gifBenemid
significance_2.gifCambia
significance_2.gifCarbenicillin
significance_2.gifCataflam
significance_2.gifCetraxal
significance_2.gifChildren's advil
significance_2.gifChildren's advil flavored
significance_2.gifChildren's elixsure
significance_2.gifChildren's ibuprofen
significance_2.gifChildren's motrin
significance_2.gifCiloxan
significance_2.gifCipro
significance_2.gifCipro IV
significance_2.gifCipro XR
significance_2.gifCiprofloxacin
significance_2.gifClinoril
significance_2.gifCo-trimoxazole
significance_2.gifDaypro
significance_2.gifDexilant
significance_2.gifDexlansoprazole
significance_2.gifDiclofenac
significance_2.gifDiflunisal
significance_2.gifDispermox
significance_2.gifDolobid
significance_2.gifEC-Naprosyn
significance_2.gifEsomeprazole
significance_2.gifEtodolac
significance_2.gifFeldene
significance_2.gifFenoprofen
significance_2.gifFlector
significance_2.gifFlurbiprofen
significance_2.gifGeocillin
significance_2.gifIbu-tab
significance_2.gifIbu-tab 200
significance_2.gifIbuprofen
significance_2.gifIbuprohm
significance_2.gifIndocin
significance_2.gifIndomethacin
significance_2.gifInfants' advil
significance_2.gifInfants' motrin
significance_2.gifJunior strength advil
significance_2.gifJunior strength ibuprofen
significance_2.gifJunior strength motrin
significance_2.gifKapidex
significance_2.gifKetoprofen
significance_2.gifKetorolac
significance_2.gifLansoprazole
significance_2.gifLarotid
significance_2.gifLodine
significance_2.gifMeclofenamate
significance_2.gifMefenamic acid
significance_2.gifMeloxicam
significance_2.gifMezlin
significance_2.gifMezlocillin
significance_2.gifMidol Extended Relief
significance_2.gifMidol liquid gels
significance_2.gifMobic
significance_2.gifMotrin
significance_2.gifMotrin IB
significance_2.gifMotrin migraine pain
significance_2.gifMoxatag
significance_2.gifNabumetone
significance_2.gifNalfon
significance_2.gifNaprelan
significance_2.gifNaprosyn
significance_2.gifNaproxen
significance_2.gifNexcede
significance_2.gifNexium
significance_2.gifNexium IV
significance_2.gifOcufen
significance_2.gifOmeprazole
significance_2.gifOrudis
significance_2.gifOxacillin
significance_2.gifOxaprozin
significance_2.gifPamprin All Day
significance_2.gifPantoprazole
significance_2.gifPediaCare Children's Pain Reliever/ Fever Reducer IB
significance_2.gifPediaCare Infants' Pain Reliever/ Fever Reducer IB
significance_2.gifPediatric advil
significance_2.gifPennsaid
significance_2.gifPiperacillin
significance_2.gifPipracil
significance_2.gifPiroxicam
significance_2.gifPonstel
significance_2.gifPrevacid
significance_2.gifPrevacid 24 HR OTC
significance_2.gifPrilosec
significance_2.gifPrilosec OTC
significance_2.gifProbalan
significance_2.gifProbenecid
significance_2.gifProfen
significance_2.gifProquin XR
significance_2.gifProtonix
significance_2.gifProtonix IV
significance_2.gifRabeprazole
significance_2.gifRelafen
significance_2.gifSalicylates
significance_2.gifSeptra
significance_2.gifSolaraze
significance_2.gifSprix
significance_2.gifSulindac
significance_2.gifTab-profen
significance_2.gifThiazide Diuretics
significance_2.gifTivorbex
significance_2.gifTolectin
significance_2.gifTolmetin
significance_2.gifToradol
significance_2.gifVoltaren
significance_2.gifVoltaren Gel
significance_2.gifVoltaren ophthalmic
significance_2.gifVoltaren-XR
significance_2.gifZipsor
significance_2.gifZorvolex

Pregnancy/Breast Feeding

Pregnancy Category:X

Breastfeeding: Unsafe; Breastfeeding is contraindicated during maternal antineoplastic drug therapy. It is considered that low single or weekly doses, such as those used for rheumatoid arthritis, are of low risk to the breastfed infant. Monitor breastfed infants with a complete blood count if methotrexate is used during lactation. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 11 April 2011). According to manufacturer's data use of this drug is contraindicated in nursing mothers.

Adverse Reactions

Clinical Pharmacology

Brands and Availability

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US Trade Name(s)

US Availability

methotrexate (generic)

Otrexup

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Canadian Trade Name(s)

Canadian Availability

methotrexate (generic)

Metoject

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UK Trade Name(s)

UK Availability

methotrexate (generic)

Metoject

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Australian Trade Name(s)

Australian Availability

methotrexate (generic)


[Outline]

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Classification

Dermatologic

Antipsoriatic Agents

Hematology/Oncology

Antineoplastics
Antimetabolites

Rheumatologic

Antirheumatic Agents

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.