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Use and Dosing

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Primary hyperlipidemia

Homozygous Familial Hypercholesterolemia

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Heterozygous Familial Hypercholesterolemia (10-17 yrs)


[Outline]

Indications

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment

Hepatic Dose Adjustment

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in

Supplemental Patient Information

Pregnancy/Breast Feeding

Pregnancy Category:X

Breastfeeding: Safety unknown; No published data on the use of ezetimibe and simvastatin during breastfeeding. It is best not use during breastfeeding as a concern with disruption of infant lipid metabolism. Ezetimibe in combination with a statin (e.g., atorvastatin, simvastatin) should be avoided in nursing mothers. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 18 February 2011). Because of the potential for serious adverse reactions in nursing infants, manufacturer suggests not to use ezetimibe/simvastatin during breastfeeding.

Adverse Reactions

Clinical Pharmacology

Ezetimibe

Simvastatin

Brands and Availability

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US Trade Name(s)

US Availability

Vytorin (ezetimibe/simvastatin)

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Canadian Trade Name(s)

Canadian Availability

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UK Trade Name(s)

UK Availability

Inegy (ezetimibe/simvastatin)

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Australian Trade Name(s)

Australian Availability

Vytorin (ezetimibe/simvastatin)


[Outline]

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Classification

Endocrine/Metabolic

Antihyperlipidemic Agents
Antihyperlipidemic Combinations

Cardiovascular

Antihyperlipidemic Agents
Antihyperlipidemic Combinations

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill