Adult Dosing

Increased IOP

• Instill 1 gtt in affected eye(s) tid

Pediatric Dosing

Increased IOP

• (>2yrs): Instill 1 gtt in affected eye(s) tid

[Outline]

• Adult Dosing
• Pediatric Dosing

• Elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension

• Hypersensitivity to any of the ingredients of the product
• MAO inhibitors use within 14 days
• Neonates and infants (under the age of 2 yrs)

• N/A

Renal Dose Adjustment

• Renal impairment: Caution advised; dose adjustment not defined

Hepatic Dose Adjustment

• Hepatic impairment: Caution advised; dose adjustment not defined

• Safety and efficacy not established in children < 2 yrs of age
• Not studied in patients with hepatic or renal impairment
• Monitor IOP periodically

Cautions: Use cautiously in

• Renal impairment
• Hepatic impairment
• Severe cardiovascular disease
• Coronary insufficiency
• Cerebrovascular disease
• CNS depressant use (additive effect for depression)
• Depression
• Raynaud's syndrome
• Orthostatic hypertension
• Thromboangitis obliterans

Pregnancy Category:B

Breastfeeding: Safety unknown; however, minimal systemic absorption, would not be expected to cause any adverse effects in the breastfed infants

• LOCAL: Allergic conjunctivitis, conjunctival hyperemia, ocular dryness/pruritus/burning, conjunctival follicles
• CNS: Somnolence
• CV: Hypertension
• EENT: Visual disturbances

• Alpha adrenergic receptor agonist; reduces aqueous humor production and increases uveoscleral outflow
• Minimal systemic absorption occurs after ophthalmic application
• Extensively metabolized by Liver
• Renally excreted (74%)
• Half-Life: 2-3 hrs

US Trade Name(s)

• Alphagan P

US Availability

brimonidine (generic)

• OPTH SOLN: 0.15% (5, 10, 15 mL)
• OPTH SOLN: 0.2% (5, 10, 15 mL)

Alphagan P

• OPTH SOLN: 0.1% (5, 10, 15 mL)
• OPTH SOLN: 0.15% (5, 10, 15 mL)

Canadian Trade Name(s)

• Alphagan
• Alphagan P

Canadian Availability

brimonidine (generic)

• OPTH SOLN: 0.15% (5, 10, 15 mL)
• OPTH SOLN: 0.2% (5, 10, 15 mL)

Alphagan

• OPTH SOLN: 0.2%

Alphagan P

• OPTH SOLN: 0.15% (3, 5, 10, 15 mL)

UK Trade Name(s)

• Alphagan

UK Availability

Alphagan

• OPTH SOLN: 0.2% (2.5, 5, 10 mL)

Australian Trade Name(s)

• Alphagan
• Enidin

Australian Availability

Alphagan

• OPTH SOLN: 0.2% (5 mL)

Enidin

• OPTH SOLN: 0.2% (5 mL)

[Outline]

Ophthalmic

Ophthalmic Glaucoma Agents

Alpha-2 Agonist

Pricing data from www.DrugStore.com in U.S.A.

• Alphagan P 0.1 % SOLN [Bottle] (ALLERGAN)
  10 % = $154.95
  30 % = $439.9
• Brimonidine Tartrate 0.15 % SOLN [Bottle] (SANDOZ)
  10 % = $134.99
  30 % = $376.97
• Brimonidine Tartrate 0.2 % SOLN [Bottle] (BAUSCH & LOMB)
  5 % = $19.99
  15 % = $49.97
• Alphagan P 0.15 % SOLN [Bottle] (ALLERGAN)
  5 % = $88.55
  15 % = $254.85
• Alphagan P 0.1 % SOLN [Bottle] (ALLERGAN)
  5 % = $78.99
  15 % = $215.98
• Alphagan P 0.1 % SOLN [Bottle] (ALLERGAN)
  15 % = $232.95
  45 % = $640.6
• Brimonidine Tartrate 0.15 % SOLN [Bottle] (SANDOZ)
  5 % = $72.99
  15 % = $186.97
• Brimonidine Tartrate 0.15 % SOLN [Bottle] (SANDOZ)
  15 % = $185.99
  45 % = $542.97
• Alphagan P 0.15 % SOLN [Bottle] (ALLERGAN)
  10 % = $168.99
  30 % = $472.97
• Brimonidine Tartrate 0.2 % SOLN [Bottle] (BAUSCH & LOMB)
  15 % = $52.99
  45 % = $139.46
• Alphagan P 0.15 % SOLN [Bottle] (ALLERGAN)
  15 % = $259.99
  45 % = $735.99

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.