Adult Dosing
Inflammatory ocular condition with superficial bacterial infection
- Instill SUSP 1 gtt into the conjunctival sac bid-qid, may increase to 1 gtt qhr during initial 24-48 hours
- Alt: Apply 0.5 inch ribbon OINT in the conjunctival sac Daily to Three times a day
Note:
- If signs and symptoms fail to improve after two days, re-evaluate the patient
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
[Outline]
See Supplemental Patient Information
- Long term opthalmic use of corticosteroids can result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision, and in posterior subcapsular cataract formation
- Prolonged use of corticosteroids can suppress the host response and thus increase the risk of secondary ocular infections
- Corneal and scleral thinning has been reported with long term use of topical corticosteroids and use of topical corticosteroids in the presence of thin corneal or scleral tissue can result in perforation
- Presence of corticosteroid medication can mask or enhance the acute purulent infections of the eye
- Monitor intraocular pressure routinely if gentamicin/prednisolone used for 10 days or longer. Use cautiously in the presence of glaucoma
- There can be increase in the incidence of bleb formation and delay healing, if steroids is used after cataract surgery
- Use of ocular steroids can exacerbate the severity of viral infections of the eye, hence use with extreme caution in patients with a history of herpes simplex and perform frequent slit lamp microscopy
- Sterile ophthalmic suspension should never be injected subconjunctivally, nor should it be directly introduced into the anterior chamber of the eye
- Gentamicin/prednisolone can cause ocular irritation and punctate keratitis
- Physician should renew medication order beyond 20 milliliters only after examination of the patient’s intraocular pressure and examination of the patient with the aid of magnification such as slit lamp biomicroscopy and fluorescein staining
- Long-term corticosteroid applications can cause fungal infections of the cornea
Cautions: Use cautiously in
- Glaucoma
- Cataract surgery
- Corneal or scleral thinning
- History of herpes simplex
- Prolong use
Supplemental Patient Information
- To prevent contamination, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed
- Advise patient to discontinue use of the medication and consult a physician, if inflammation or pain persists longer than 48 hours or becomes aggravated
Pregnancy Category:C
Breastfeeding: Safety unknown, however minimal systemic absorption following topical administration. Maternal use of gentamicin ophthalmic presents little or no risk for the nursing infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 23 March 2011). It is unknown whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. However systemic administration of corticosteroids appear in breast milk and could suppress growth, interfere with endogenous corticosteroid production, or cause untoward effects in breastfed infants. Because of the potential for serious adverse reactions in nursing infants, manufacturer recommends decision should be made whether to discontinue nursing while the drug is being administered or to discontinue the medication.
US Trade Name(s)
US Availability
Pred-G (gentamicin/prednisolone )
- OPTH SUSP: 0.3%/1.0%
- OPTH OINT: 0.3%/0.6%
Canadian Trade Name(s)
Canadian Availability
UK Trade Name(s)
UK Availability
Australian Trade Name(s)
Australian Availability
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Pred-G 0.3-1 % SUSP [Bottle] (ALLERGAN)
5 % = $39.99
15 % = $99.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.