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General Reference ⬇

Ann IM 1989;110:9

Pathophys and Cause ⬆ ⬇

Cause:Staphylococcus epidermidis(coagulase-negative staph) Pathophys:Enmeshes in glycocalyx coating of catheters and prosthetics

Epidemiology ⬆ ⬇

Normal skin inhabitant. Most common cause of hospital-acquired bacteremia; often catheter-, prosthesis-, or vascular graft-associated

Signs and Symptoms ⬆ ⬇

Si:Infections of implanted prosthetics

Complications ⬆ ⬇

30% mortality with bacteremia

Lab and Xray ⬆ ⬇

Lab:Bact:Culture, coagulase-negative staph. r/o Staph. saprophyticus, also a pathogen at least in urinary tract

Treatment ⬆

Rx:>60% are methicillin-resistant; 1st vancomycin, but some resistance (Nejm 1987;316:927); rifampin; gentamicin