Adult Dosing

Ocular infections, bacterial

• Instill 1-2 gtts in affected eye(s) q4 hrs; may start 2 gtts q1 hr in severe infections
• Alt: Apply 0.5 inch ribbon OINT to lower conjunctival sac bid-tid

Pediatric Dosing

Ocular infections, bacterial

• Instill 1-2 gtts in affected eye(s) q4 hrs; may start 2 gtts q1 hr in severe infections
• Alt: Apply 0.5 inch ribbon OINT to lower conjunctival sac bid-tid

[Outline]

• Adult Dosing
• Pediatric Dosing

• Ocular bacterial infections (conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, and dacryocystitis) caused by susceptible organisms

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

See Supplemental Patient Information

• It is for ophthalmic administration only; do not introduce into the anterior chamber of the eye
• Prolonged use may result in overgrowth of nonsusceptible organisms particularly fungi; institute appropriate therapy if new infections develop
• Discontinue use if irritation or hypersensitivity occurs

Supplemental Patient Information

• To prevent contamination, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed

Pregnancy Category:C

Breastfeeding: Safety unknown, however minimal systemic absorption following topical administration. Maternal use of gentamicin ophthalmic presents little or no risk for the nursing infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 23 August 2010)

• EENT: Ocular burning/irritation, conjunctivitis, conjunctival epithelial defects, conjunctival hyperemia
• HYPERSENSITIVITY: Allergic reactions
• HEMA: Thrombocytopenic purpura
• PSYCHIATRY: Hallucinations

• Aminoglycoside; bactericidal, binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis
• Minimal systemic absorption following ophthalmic administration
• Renally excreted (primarily unchanged)
• Half-life: 2-4 hrs

US Trade Name(s)

• Genoptic
• Gentak

US Availability

gentamicin (generic)

• OPTH SOLN: 0.3% (5 mL)
• OPTH OINT: 0.3% (3.5 g)

Genoptic

• OPTH SOLN: 0.3%

Gentak

• OPTH SOLN: 0.3% (5 mL)

Canadian Trade Name(s)

• Diogent
• Garamycin
• Gent-AK
• Gentak

Canadian Availability

gentamicin (generic)

• OPTH SOLN: 0.3%
• OPTH OINT: 0.3%

Diogent, Garamycin

• OPTH OINT: 0.3%
• OPTH SOLN: 0.3%

Gent-AK

• OPTH SOLN: 5 mg/mL

Gentak

• OPTH OINT: 0.3%

UK Trade Name(s)

• Genticin

UK Availability

gentamicin (generic)

• OPTH SOLN: 0.3% (10 mL)

Genticin

• OPTH SOLN: 0.3% (10 mL)

Australian Trade Name(s)

• Genoptic

Australian Availability

gentamicin (generic)

• OPTH SOLN (single dose): 0.3% (0.5 mL)

Genoptic

• OPTH SOLN: 3 mg/mL (5 mL)

[Outline]

Antimicrobials

Ophthalmic Anti-infectives

Infectious Disease

Ophthalmic Anti-infectives

Ophthalmic

Ophthalmic Anti-infectives