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Use and Dosing

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Hypercholesterolemia or prevention of cardiovascular events

Patients with Homozygous Familial Hypercholesterolemia

Coadministration with Other Drugs

Note:

Hyper-IgD Syndrome (HIDS) [Non-FDA Approved]

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Patients with heterozygous Familial Hypercholesterolemia (10-17 yrs)


[Outline]

Indications

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment:

Hepatic Dose Adjustment:

Warnings/Precautions

Cautions: Use cautiously in

Interactions

Zocor interacts with :

significance_3.gifAcenocoumarol
significance_2.gifAgenerase
significance_2.gifAkne-mycin
significance_2.gifAmiodarone
significance_2.gifAmprenavir
significance_2.gifAprepitant
significance_2.gifAtazanavir
significance_3.gifBarbiturates
significance_2.gifBiaxin
significance_2.gifBiaxin XL
significance_3.gifBosentan
significance_3.gifCalan
significance_3.gifCalan SR
significance_3.gifCarbamazepine
significance_3.gifCarbatrol
significance_3.gifCardizem
significance_3.gifCardizem CD
significance_3.gifCardizem LA
significance_3.gifCartia XT
significance_2.gifCetraxal
significance_2.gifCiloxan
significance_2.gifCipro
significance_2.gifCipro IV
significance_2.gifCipro XR
significance_2.gifCiprofloxacin
significance_2.gifClarithromycin
significance_2.gifConivaptan
significance_2.gifCordarone
significance_3.gifCoumadin
significance_3.gifCovera-HS
significance_2.gifCrixivan
significance_2.gifCyclosporine
significance_2.gifDanazol
significance_2.gifDanocrine
significance_2.gifDarunavir
significance_2.gifDelavirdine
significance_2.gifDiflucan
significance_3.gifDilacor XR
significance_3.gifDilantin
significance_3.gifDilantin Infatabs
significance_3.gifDilantin-125
significance_3.gifDilt-CD
significance_3.gifDiltiazem
significance_3.gifDiltzac
significance_2.gifDronedarone
significance_2.gifE-Mycin
significance_2.gifE.E.S.
significance_3.gifEfavirenz
significance_2.gifEmend
significance_3.gifEpitol
significance_3.gifEquetro
significance_2.gifEry-Tab
significance_2.gifEryc
significance_2.gifErygel
significance_2.gifEryped
significance_2.gifErythra-Derm
significance_2.gifErythro-statin
significance_2.gifErythrocin
significance_2.gifErythromycin
significance_3.gifEtravirine
significance_2.gifExtina
significance_2.gifFluconazole
significance_2.gifFluvoxamine
significance_3.gifGemfibrozil
significance_2.gifGengraf
significance_2.gifGleevec
significance_2.gifGrapefruit
significance_2.gifImatinib
significance_2.gifIncivek
significance_2.gifIndinavir
significance_3.gifIntelence
significance_2.gifInvirase
significance_3.gifIsoptin
significance_3.gifIsoptin SR
significance_2.gifItraconazole
significance_3.gifJantoven
significance_2.gifKetek
significance_2.gifKetoconazole
significance_3.gifLopid
significance_2.gifLuvox
significance_2.gifLuvox CR
significance_2.gifMultaq
significance_3.gifMycobutin
significance_3.gifMysoline
significance_2.gifNefazodone
significance_2.gifNelfinavir
significance_2.gifNeoral
significance_3.gifNevirapine
significance_2.gifNexterone
significance_2.gifNizoral
significance_2.gifNizoral A-D Shampoo
significance_2.gifNizoral Shampoo
significance_2.gifNorvir
significance_2.gifNoxafil
significance_2.gifOnmel
significance_3.gifOxcarbazepine
significance_3.gifOxtellar XR
significance_2.gifPacerone
significance_2.gifPCE
significance_2.gifPediamycin
significance_3.gifPhenytek
significance_3.gifPhenytoin
significance_2.gifPosaconazole
significance_2.gifPrezista
significance_3.gifPriftin
significance_3.gifPrimidone
significance_2.gifProquin XR
significance_2.gifQuinupristin
significance_2.gifRescriptor
significance_2.gifRestasis
significance_2.gifReyataz
significance_3.gifRifabutin
significance_3.gifRifadin
significance_3.gifRifampin
significance_3.gifRifapentine
significance_3.gifRimactane
significance_2.gifRitonavir
significance_2.gifSandimmune
significance_2.gifSaquinavir
significance_2.gifSporanox
significance_3.gifSt. John's Wort
significance_3.gifSustiva
significance_2.gifSynercid
significance_2.gifTAO
significance_3.gifTaztia XT
significance_3.gifTegretol
significance_3.gifTegretol XR
significance_2.gifTelaprevir
significance_2.gifTelithromycin
significance_3.gifTeril
significance_3.gifTiazac
significance_3.gifTracleer
significance_3.gifTrileptal
significance_2.gifTroleandomycin
significance_2.gifVaprisol
significance_3.gifVeralan
significance_3.gifVerapamil
significance_3.gifVerelan PM
significance_2.gifVfend
significance_2.gifViracept
significance_3.gifViramune
significance_3.gifViramune XR
significance_2.gifVoriconazole
significance_3.gifWarfarin
significance_2.gifXolegel

Pregnancy/Breast Feeding

Pregnancy Category:X

Breastfeeding: Limited published data exist to define the safety of breastfeeding; due to potential for serious adverse reactions and disruption of infant lipid metabolism, breastfeeding is not recommended. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 16 March 2011). Small amount of another drug in this class is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants manufacturer recommends either discontinue nursing or discontinue drug, taking into account the importance of the drug to the mother.

Adverse Reactions

Clinical Pharmacology

Brands and Availability

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US Trade Name(s)

US Availability

simvastatin (generic)

Zocor

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Canadian Trade Name(s)

Canadian Availability

simvastatin (generic)

Zocor

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UK Trade Name(s)

UK Availability

simvastatin (generic)

Simvador

Zocor

Zocor Heart-Pro

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Australian Trade Name(s)

Australian Availability

simvastatin (generic)

Lipex, Ransim, Simvar

Simvabell

Simvahexal

Simvasyn, Zimstat, Zocor


[Outline]

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Classification

Endocrine/Metabolic

Antihyperlipidemic Agents
HMG-CoA Reductase Inhibitors (Statins)

Cardiovascular

Antihyperlipidemic Agents
HMG-CoA Reductase Inhibitors (Statins)

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill