acyclovir [Buccal]

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Use and Dosing ⬇

Adult Dosing

Recurrent herpes labialis (cold sores) in immunocompetent adults

Apply 50 mg tablet as a single dose to the upper gum (canine fossa) region

Pediatric Dosing

Safety and effectiveness in pediatric patients have not been established

[Outline]

Adult Dosing
Pediatric Dosing

Indications ⬆ ⬇

Recurrent herpes labialis (cold sores) in immunocompetent adults

Contraindications ⬆ ⬇

Hypersensitivity to any of the ingredients of the product
Known hypersensitivity to acyclovir or milk protein concentrate

Black Box Warnings ⬆ ⬇

Dosing Adjustment ⬆ ⬇

Renal Dose Adjustment (Based on CrCl)

Renal impairment: Caution advised; dose adjustments not defined

Hepatic Dose Adjustment

Hepatic impairment: Caution advised; dose adjustments not defined

Warnings/Precautions ⬆ ⬇

Safety of acyclovir has not been studied in immunocompromised patients; use cautiously

Pregnancy/Breast Feeding ⬆ ⬇

Pregnancy Category:B

Breastfeeding: With highest maternal dosages, the amount excreted in breast milk is equivalent to 1% of a typical infant dosage. Since it is excreted in negligible amounts, it would not be expected to cause any adverse effects in breastfed infants. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 23 April 2013). Manufacturer advises caution.

Adverse Reactions ⬆ ⬇

CNS: Headache, dizziness, lethargy
GI: Gingival pain, aphthous stomatitis
DERM: Erythema, rash
HYPERSENSITIVITY: Application site pain, application site irritation

Clinical Pharmacology ⬆ ⬇

Antiviral; competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, and incorporates into viral DNA, then inhibits DNA synthesis by acting as a chain terminator
Metabolism: Metabolised by liver to 9-[(carboxymethoxy)methyl]guanine (CMMG) and 8hydroxy-acyclovir (8-OH-ACV) by oxidation and hydroxylation
Excretion: Primarily excreted unchanged by the kidneys
Half-life: Unknown