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Use and Dosing

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Contraception

Balziva-28, Briellyn, Gildagia, Ovcon-35, Philith, Zenchent (ethinyl estradiol 0.035 mg/norethindrone 0.4 mg)

Brevicon 28-Day, Modicon 28, Necon 0.5/35, Wera (ethinyl estradiol 0.035 mg/norethindrone 0.5 mg)

Alyacen 1/35, Aranelle, Cyclafem 1/35, Dasetta 1/35, Necon 1/35, Norethin 1/35E-28, Ortho-Novum 1/35 (ethinyl estradiol 0.035 mg/norethindrone 1 mg)

Femcon Fe, Zenchent Fe, Zeosa (ethinyl estradiol 0.035 mg/norethindrone 0.4 mg)

Generess Fe (ethinyl estradiol 0.025 mg/norethindrone 0.8 mg)

Gildess Fe 1.5/30, Junel Fe 1.5/30, Loestrin Fe 1.5/30, Microgestin Fe 1.5/30, Larin Fe 1.5/30 (ethinyl estradiol 0.03 mg/norethindrone 1.5 mg)

Gildess Fe 1/20, Junel Fe 1/20, Loestrin Fe 1/20, Microgestin Fe 1/20, Larin Fe 1/20 (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Junel 1.5/30, Loestrin 21 1.5/30, Microgestin 1.5/30 (ethinyl estradiol 0.03 mg/norethindrone 1.5 mg)

Junel 1/20, Loestrin 21 1/20, Microgestin 1/20 (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Lo Loestrin Fe (ethinyl estradiol 0.01 mg/norethindrone 1 mg)

Loestrin 24 Fe (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Norethin 1/35E-21 (ethinyl estradiol 0.035 mg/norethindrone 1 mg)

Nortrel 1/35, Norinyl 1+35 (ethinyl estradiol 0.035 mg/norethindrone 1 mg)

Nortrel 0.5/35 (ethinyl estradiol 0.035 mg/norethindrone 0.5 mg)

Ovcon-50 (ethinyl estradiol 0.05 mg/norethindrone 1 mg)

Minastrin 24 Fe (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Note:

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Contraception (postpubertal adolescents)

Balziva-28, Briellyn, Gildagia, Ovcon-35, Philith, Zenchent (ethinyl estradiol 0.035 mg/norethindrone 0.4 mg)

Brevicon 28-Day, Modicon 28, Necon 0.5/35, Wera (ethinyl estradiol 0.035 mg/norethindrone 0.5 mg)

Alyacen 1/35, Aranelle, Cyclafem 1/35, Dasetta 1/35, Necon 1/35, Norethin 1/35E-28, Ortho-Novum 1/35 (ethinyl estradiol 0.035 mg/norethindrone 1 mg)

Femcon Fe, Zenchent Fe, Zeosa (ethinyl estradiol 0.035 mg/norethindrone 0.4 mg)

Generess Fe (ethinyl estradiol 0.025 mg/norethindrone 0.8 mg)

Gildess Fe 1.5/30, Junel Fe 1.5/30, Loestrin Fe 1.5/30, Microgestin Fe 1.5/30 (ethinyl estradiol 0.03 mg/norethindrone 1.5 mg)

Gildess Fe 1/20, Junel Fe 1/20, Loestrin Fe 1/20, Microgestin Fe 1/20, Larin Fe 1/20 (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Junel 1.5/30, Loestrin 21 1.5/30, Microgestin 1.5/30, Larin Fe 1.5/30 (ethinyl estradiol 0.03 mg/norethindrone 1.5 mg)

Junel 1/20, Loestrin 21 1/20, Microgestin 1/20 (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Lo Loestrin Fe (ethinyl estradiol 0.01 mg/norethindrone 1 mg)

Loestrin 24 Fe (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Norethin 1/35E-21 (ethinyl estradiol 0.035 mg/norethindrone 1 mg)

Nortrel 1/35, Norinyl 1+35 (ethinyl estradiol 0.035 mg/norethindrone 1 mg)

Nortrel 0.5/35 (ethinyl estradiol 0.035 mg/norethindrone 0.5 mg)

Ovcon-50 (ethinyl estradiol 0.05 mg/norethindrone 1 mg)

Contraception

Minastrin 24 Fe (ethinyl estradiol 0.02 mg/norethindrone 1 mg)

Note:


[Outline]

Indications

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment

Hepatic Dose Adjustment

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in

Supplemental Patient Information

Pregnancy/Breast Feeding

Pregnancy Category:X

Breastfeeding: Combination oral contraceptives probably do not affect the composition of milk substantially in healthy, well-nourished mothers and do not adversely affect long-term infant growth and development, but can transiently affect growth negatively during the first month after introduction. Rarely, reversible breast enlargement has been reported with higher doses of estrogen. Ethinyl estradiol in doses of 30 mcg daily or greater can suppress lactation leading to earlier discontinuation of breastfeeding than nonhormonal or progestin-only contraception. The magnitude of the effect on lactation likely depends on the dose and the time of introduction postpartum. As per US expert opinion, the risks of combination contraceptive products usually outweigh the benefits before 4 weeks postpartum. Between 4 weeks and 6 months postpartum, the advantages of using the method generally outweigh the theoretical or proven risks. After 6 months postpartum, combination contraceptives can be used, but progestin-only methods are preferred if breastfeeding will be continued. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 24 June 2011).Small amounts of oral contraceptive steroids are excreted in breastmilk of nursing mothers and a few adverse effects on the child have occurred, including jaundice and breast enlargement. Combination oral contraceptives given in the postpartum period may interfere with lactation by decreasing the quantity and quality of breast milk. Manufacturer advises the nursing mother to avoid using combination oral contraceptives and to use other forms of contraception until she has completely weaned her child.

Adverse Reactions

Clinical Pharmacology

Ethinyl estradiol

Norethindrone

Brands and Availability

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US Trade Name(s)

US Availability

ethinyl estradiol/norethindrone (generic)

Balziva-28, Briellyn, Gildagia, Ovcon-35, Philith, Zenchent (ethinyl estradiol/norethindrone)

Brevicon 28-Day, Modicon 28, Necon 0.5/35, Wera (ethinyl estradiol/norethindrone)

Alyacen 1/35, Aranelle, Cyclafem 1/35, Dasetta 1/35, Necon 1/35, Norethin 1/35E-28, Ortho-Novum 1/35 (ethinyl estradiol/norethindrone)

Zenchent Fe, Zeosa (ethinyl estradiol/norethindrone)

Generess Fe (ethinyl estradiol/norethindrone)

Gildess Fe 1.5/30, Junel Fe 1.5/30, Loestrin Fe 1.5/30, Microgestin Fe 1.5/30, Larin Fe 1.5/30 (ethinyl estradiol/norethindrone)

Gildess Fe 1/20, Junel Fe 1/20, Loestrin Fe 1/20, Microgestin Fe 1/20, Larin Fe 1/20 (ethinyl estradiol/norethindrone)

Junel 1.5/30, Loestrin 21 1.5/30, Microgestin 1.5/30 (ethinyl estradiol/norethindrone)

Junel 1/20, Loestrin 21 1/20, Microgestin 1/20, Larin 1/20 (ethinyl estradiol/norethindrone)

Lo Loestrin Fe, Lo Minastrin Fe (ethinyl estradiol/norethindrone)

Loestrin 24 Fe (ethinyl estradiol/norethindrone)

Norethin 1/35E-21 (ethinyl estradiol/norethindrone)

Nortrel 1/35, Norinyl 1+35 (ethinyl estradiol/norethindrone)

Nortrel 0.5/35 (ethinyl estradiol/norethindrone)

Ovcon-50

Femcon Fe

Minastrin 24 Fe (ethinyl estradiol/norethindrone)

Femhrt (ethinyl estradiol/norethindrone)

Vyfemla (ethinyl estradiol/norethindrone)

Larin 1.5/30 (ethinyl estradiol/norethindrone)

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Canadian Trade Name(s)

Canadian Availability

Brevicon 0.5/35, Ortho 0.5/35 (ethinyl estradiol/norethindrone)

Brevicon 1/35, Ortho 1/35, Select 1/35 (ethinyl estradiol/norethindrone)

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UK Trade Name(s)

UK Availability

Brevinor, Ovysmen (ethinyl estradiol/norethisterone)

Norimin (ethinylestradiol/norethisterone)

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Australian Trade Name(s)

Australian Availability

Brevinor 21 Day (ethinyloestradiol/norethisterone)

Brevinor 28 Day (ethinyloestradiol/norethisterone)

Brevinor-1 21 (ethinyloestradiol/norethisterone)

Brevinor-1 28 (ethinyloestradiol/norethisterone)


[Outline]

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Classification

Obstetrics/Gynecology

Contraceptives
Estrogen And Progestin Combination

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill

Drug Name: Femcon FE 28 Day Pack

Ingredient(s): Ethinyl Estradiol mixture with Ferrous fumarate and Norethindrone

Imprint: PD;622

Color(s): Brown

Shape: Round

Size (mm): 6.00

Score: 1

Inactive Ingredient(s): ferrous fumarate / cellulose, microcrystalline / magnesium stearate / povidone / sodium starch glycolate type a potato

Drug Label Author:
Warner Chilcott (US), LLC

DEA Schedule:
Non-Scheduled


Drug Name: Zenchent 28 Day Pack

Ingredient(s): Ethinyl Estradiol mixture with Inert Ingredients and Norethindrone

Imprint: WC;781

Color(s): White

Shape: Capsule

Size (mm): 7.00

Score: 1

Inactive Ingredient(s): lactose monohydrate / magnesium stearate / starch, corn

Drug Label Author:
Watson Pharma, Inc.

DEA Schedule:
Non-Scheduled