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Drugs that Increase the QT Interval

This chart lists the drugs that have been shown to increase the QT interval, which increases the patient’s risk of developing torsades de pointes.

Drug nameDrug class
Amiodarone (Cordarone) or (Pacerone)Antiarrhythmic
Amitriptyline (Elavil)Antidepressant
ChlorpromazineAntipsychotic/antiemetic
Clarithromycin (Biaxin)Antibiotic
Desipramine (Norpramin)Antidepressant
Disopyramide (Norpace)Antiarrhythmic
Dofetilide (Tikosyn)Antiarrhythmic
Dolasetron (Anzemet)Antiemetic
Droperidol (Inapsine)Sedative; antinauseant
Erythromycin (Erythrocin)Antibiotic; gastrointestinal stimulant
Fluoxetine (Prozac)Antidepressant
Haloperidol (Haldol)Antipsychotic
Ibutilide (Corvert)Antiarrhythmic
Ketoconazole (Nizoral)Antifungal
Levofloxacin (Levaquin)Antibiotic
Methadone (Methadose or Dolophine)Opiate agonist
ProcainamideAntiarrhythmic
Quinidine sulphateAntiarrhythmic
Sertraline (Zoloft)Antidepressant
Sotalol (Betapace)Antiarrhythmic
Sumatriptan (Imitrex)Antimigraine
Thioridazine (Mellaril)Antipsychotic