Hypothesis for Etiologic Cascade of Painful Bladder Syndrome/Interstitial Cystitis - Flowchart

Hypothesis for Etiologic Cascade of Painful Bladder Syndrome/Interstitial Cystitis - Flowchart

Hypothesis for Etiologic Cascade of Painful Bladder Syndrome/Interstitial Cystitis - Flowchart Bladder Pain Syndrome Bladder Pain Syndrome

«Flowchart»

Start

Start

Start

Pelvic floor dysfunction??

Pelvic floor dysfunction??

Pelvic floor dysfunction??

Autoimmune disorder??

Autoimmune disorder??

Autoimmune disorder??

Bacterial cystitis??

Bacterial cystitis??

Bacterial cystitis??

Primary neurogenic inflammation??

Primary neurogenic inflammation??

Primary neurogenic inflammation??

Bladder trauma??

Bladder trauma??

Bladder trauma??

Bladder overdistention??

Bladder overdistention??

Bladder overdistention??

BLADDER INSULT

BLADDER INSULT

BLADDER INSULT

Damage to bladder epithelium

Damage to bladder epithelium

Damage to bladder epithelium

Antiproliferative factor secreted by epithelial cells

Antiproliferative factor secreted by epithelial cells

Antiproliferative factor secreted by epithelial cells

Bladder fails to repair damage

Bladder fails to repair damage

Bladder fails to repair damage

Possibility of chronic neuropathic pain

Possibility of chronic neuropathic pain

Possibility of chronic neuropathic pain

End

End

End

Mast cell activation and histamine release

Mast cell activation and histamine release

Mast cell

Progressive bladder injury

Progressive bladder injury

Progressive

Mast cell activation and histamine release

Mast cell activation and histamine release

Mast cell

Progressive bladder injury

Progressive bladder injury

Progressive

Spinal cord changes

Spinal cord changes

Spinal cord

Leak of urine constituents (potassium) into interstitium

Leak of urine constituents (potassium) into interstitium

Leak of urine

Leak of urine constituents (potassium) into interstitium

Leak of urine constituents (potassium) into interstitium

Leak of urine constituents (potassium) into interstitium

Mast cell activation and histamine release

Mast cell activation and histamine release

Mast cell activation and histamine release

Mast cell activation and histamine release

Mast cell activation and histamine release

Mast cell activation and histamine release

C-fiber activation; substance P release

C-fiber activation; substance P release

C-fiber

Progressive bladder injury

Progressive bladder injury

Progressive

Immunogenic and allergic responses

Immunogenic and allergic responses

Immunogenic