Management of Recurrent and Metastatic Breast Cancer - Flowchart
Management of Recurrent and Metastatic Breast Cancer - Flowchart Breast Cancer Breast Cancer
«Flowchart»

Determine hormone receptor and HER2 status

Determine hormone receptor and HER2 status

Determine hormone receptor and HER2 status

ER +

ER +

ER +

ER –

ER –

ER –

Evaluate clinicopathologic features

Evaluate clinicopathologic features

Evaluate clinicopathologic features

Chemotherapy + trastuzumab + endocrine therapy

Chemotherapy + trastuzumab + endocrine therapy

Chemotherapy + trastuzumab + endocrine therapy

HER2 +

HER2 +

HER2 HER2 +

HER2 –

HER2 –

HER2 HER2 –

End

End

End

Consider multigene assay

Consider multigene assay

Consider multigene assay

Consider multigene assay

Chemotherapy

Chemotherapy

Chemotherapy

Chemotherapy

Endocrine therapy

Endocrine therapy

Endocrine therapy

Endocrine therapy

Features favoring endocrine therapy alone

Features favoring endocrine therapy alone

Features favoring endocrine therapy alone

Indeterminate features

Indeterminate features

Indeterminate features

Features favoring chemotherapy

Features favoring chemotherapy

Features favoring chemotherapy

Chemotherapy + trastuzumab

Chemotherapy + trastuzumab

Chemotherapy + trastuzumab

“Triple negative” disease

“Triple negative” disease

“Triple negative” disease

HER2 +

HER2 +

HER2 HER2 +

HER2 –

HER2 –

HER2 HER2 –