Pathogenesis of IgA Nephropathy - Flowchart
Pathogenesis of IgA Nephropathy - Flowchart IgA Nephropathy IgA Nephropathy
«Flowchart»

Bone marrow stem cell defect

Bone marrow stem cell defect

Bone marrow stem cell defect

Galactose-deficient IgA1

Galactose-deficient IgA1

Galactose-deficient IgA1

Production anti-IgA1 antibodies

Production anti-IgA1 antibodies

Production anti-IgA1 antibodies

In situ and circulating ICs

In situ and circulating ICs

In situ and circulating ICs

Local IC activation & injury

Local IC activation & injury

Local IC activation & injury

End

End

End

IgA, Immunoglobulin A; IC, immune complex.

IgA, Immunoglobulin A; IC, immune complex.

IgA, Immunoglobulin A; IC, immune complex.

IgA IC