Schema of Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mechanisms of Chronic Airway Disease - Flowchart
Schema of Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mechanisms of Chronic Airway Disease - Flowchart Cystic Fibrosis Cystic Fibrosis
«Flowchart»

Mutant CFTR

Mutant CFTR

Mutant CFTR

Mutant CFTR

Increased mucous viscoelasticity and airway obstruction

Increased mucous viscoelasticity and airway obstruction

Increased mucous viscoelasticity and airway obstruction

Increased oxidative stress

Increased oxidative stress

Increased oxidative stress

Impaired bacterial clearance and killing

Impaired bacterial clearance and killing

Impaired bacterial clearance and killing

Vicious cycle of infection and inflammation with airway remodeling

Vicious cycle of infection and inflammation with airway remodeling

Vicious cycle of infection and inflammation with airway remodeling

End

End

End

Impaired bacterial clearance and killing

Impaired bacterial clearance and killing

Impaired bacterial clearance and killing

Vicious cycle of infection and inflammation with airway remodeling

Vicious cycle of infection and inflammation with airway remodeling

Vicious cycle of infection

Increased mucous viscoelasticity and airway obstruction

Increased mucous viscoelasticity and airway obstruction

Increased mucous viscoelasticity

Impaired bacterial clearance and killing

Impaired bacterial clearance and killing

Impaired bacterial clearance and killing

Decreased chloride secretion and increased sodium absorption

Decreased chloride secretion and increased sodium absorption

Decreased chloride secretion

Decreased bicarbonate secretion and decreased ASL pH

Decreased bicarbonate secretion and decreased ASL pH

Decreased bicarbonate secretion

Decreased thiocyanate secretion

Decreased thiocyanate secretion

Decreased thiocyanate secretion

Decreased glutathione secrection

Decreased glutathione secrection

Decreased glutathione secrection