Propagation of the Acute Gouty Response by Activated Neutrophils - Flowchart
Propagation of the Acute Gouty Response by Activated Neutrophils - Flowchart Gout Gout
«Flowchart»

Image

Urate crystal partially ingested by neutrophil

Image

Urate crystal partially ingested by neutrophil

Image

Urate crystal partially ingested by neutrophil

Neutrophil activation

Neutrophil activation

Neutrophil activation

Image

Neutrophil lysis

Image

Neutrophil lysis

Neutrophil lysis

Release of cell contents

Release of cell contents

Release of cell contents

IL-18, IL-8, LTB4 release
Degranulation (protease release)
Reactive oxygen generation

IL-18, IL-8, LTB4 release
Degranulation (protease release)
Reactive oxygen generation

IL-18, IL-8, LTB4 release
Degranulation (protease release)
Reactive oxygen generation

4

Further neutrophil influx, inflammation, and joint damage

Further neutrophil influx, inflammation, and joint damage

Further neutrophil influx, inflammation, and joint damage

End

End

End