Pathophysiologic Factors Associated with the Development of Anemia of Chronic Disease - Flowchart
Pathophysiologic Factors Associated with the Development of Anemia of Chronic Disease - Flowchart Inflammatory Anemia Inflammatory Anemia
«Flowchart»

Cytokines

Cytokines

Cytokines

↑ Hepcidin

↑ Hepcidin

↑ ↑ Hepcidin ↑

↓ EPO and ↓ response to EPO
↓ Proliferation of erythron
↓ Red cell half-life

↓ EPO and ↓ response to EPO
↓ Proliferation of erythron
↓ Red cell half-life

↓ ↓
↓
↓ ↓ EPO ↓

End

End

End

Anemia

Anemia

Anemia

Anemia

↓ Iron availability in the erythron

↓ Iron availability in the erythron

↓ Iron availability in the erythron

↓

↓ Iron absorption

↓ Iron absorption

↓ ↓ Iron absorption ↓

↑ Iron retention in the RES

↑ Iron retention in the RES

↑ ↑ Iron retention ↑