Confirmed cryptosporidiosis

Reverse dehydration and keep hydrated during evaluation process.
If malnourished (e.g. from persistent diarrhea), begin aggressive nutritional rehabilitation which improves cell-mediated immunity. Treat any coinfections.
Consider anti-cryptosporidium therapy with drugs such as nitazoxanide, paromomycin, azithromycin if symptoms are severe or not improving with supportive therapy. No clinical studies have shown any consistent benefits with these drugs for persons with HIV/AIDS but there are anecdotal reports of success.

Evaluate for HIV/AIDS
Evaluate nutritional status and hydration

End

Reverse dehydration and keep hydrated during evaluation process.
If malnourished (e.g. from persistent diarrhea), begin aggressive nutritional rehabilitation which improves cell-mediated immunity. Treat any coinfections.
Consider anti-cryptosporidium therapy with drugs such as nitazoxanide, paromomycin, azithromycin if symptoms are severe or not improving with supportive therapy. No clinical studies have shown any consistent benefits with these drugs for persons with HIV/AIDS but there are anecdotal reports of success.

If the person has HIV/AIDS, focus on hydration and aggressive nutritional support.
Treat any coinfections.
Begin antiretroviral therapy which will, if successful, reverse the underlying immunosuppression and may allow the person to resolve the infection. This may take weeks.