Mechanisms of Muscle Fiber Damage in Myositis - Flowchart

Mechanisms of Muscle Fiber Damage in Myositis - Flowchart

Mechanisms of Muscle Fiber Damage in Myositis - Flowchart Inflammatory Myopathies Inflammatory Myopathies

«Flowchart»

Start

Start

Start

Complement

Complement

Complement

Antibodies

Antibodies

Antibodies

Cytokines

Cytokines

Cytokines

CD8⁺ T cells

CD8⁺ T cells

⁺ CD8[+] T cells

Endothelial cell damage

Endothelial cell damage

Endothelial cell damage

Class I MHC expression

Class I MHC expression

Class I MHC expression

Hypoxia

Hypoxia

Hypoxia

Capillary loss

Capillary loss

Capillary loss

Loss of skeletal muscle fibers

Loss of skeletal muscle fibers

Loss of skeletal muscle fibers

End

End

End

ER stress

ER stress

ER stress

Myofiber damage

Myofiber damage

Myofiber damage

Endothelial cell damage

Endothelial cell damage

Endothelial cell damage

Class I MHC expression

Class I MHC expression

Class I MHC expression