Many Signals Impact the Critical Points in This Pathway - Flowchart

Many Signals Impact the Critical Points in This Pathway - Flowchart

Many Signals Impact the Critical Points in This Pathway - Flowchart Gout Gout

«Flowchart»

PATHOPHYSIOLOGY OF GOUT

PATHOPHYSIOLOGY OF GOUT

PATHOPHYSIOLOGY OF GOUT

PATHOPHYSIOLOGY OF GOUT

Genetic

Genetic

Genetic

Drugs

Drugs

Drugs

Diet

Diet

Diet

Alcohol

Alcohol

Alcohol

Metabolic

Metabolic

Metabolic

Proliferative

Proliferative

Proliferative

Seed nucleus

Seed nucleus

Seed nucleus

Crystal promoters

Crystal promoters

Crystal promoters

Crystal inhibitors

Crystal inhibitors

Crystal inhibitors

Urate concentration

Urate concentration

Urate concentration

Proinflammatory coating (e.g., IgG)

Proinflammatory coating (e.g., IgG)

Proinflammatory coating

Antiinflammatory coating (e.g., apo-E)

Antiinflammatory coating (e.g., apo-E)

Antiinflammatory coating

Formation of aggregated NETs
Macrophage TGF-β, IL-10, apo-B, apo-E, PPAR-!!Gyamma!!, AMPK, MCR ligands

Formation of aggregated NETs
Macrophage TGF-β, IL-10, apo-B, apo-E, PPAR-!!Gyamma!!, AMPK, MCR ligands

β Formation of aggregated NETs

Overproduction

Overproduction

Overproduction

Underexcretion

Underexcretion

Underexcretion

Hyperuricemia

Hyperuricemia

Hyperuricemia

Supersaturation

Supersaturation

Supersaturation

Crystal formation

Crystal formation

Crystal formation

Microcrystal shedding

Microcrystal shedding

Microcrystal shedding

Resident synovial cells

Resident synovial cells

Resident synovial cells

NLRP3 inflammasome activation with mature IL-1β release

NLRP3 inflammasome activation with mature IL-1β release

NLRP3 inflammasome activation with mature IL-1β release

β

Persistent joint inflammation complement, TNF-, NO, chemokines

Persistent joint inflammation complement, TNF-, NO, chemokines

Persistent joint inflammation complement, TNF-, NO, chemokines

Neutrophils, macrophages

Neutrophils, macrophages

Neutrophils, macrophages

Adhesion molecules

Adhesion molecules

Adhesion molecules

Neutrophils, macrophages

Neutrophils, macrophages

Neutrophils, macrophages

Resolution

Resolution

Resolution

Recurrences

Recurrences

Recurrences

Persistent joint inflammation

Persistent joint inflammation

Persistent joint inflammation

End

End

End

Acute inflammatory mediators

Acute inflammatory mediators

Acute inflammatory mediators

Chemokines

Chemokines

Chemokines