Treatment Options Based on Subtype of Systemic Mastocytosis - Flowchart
Treatment Options Based on Subtype of Systemic Mastocytosis - Flowchart Mastocytosis Mastocytosis
«Flowchart»

Diagnosis of SM

Diagnosis of SM

Diagnosis of SM

Midostaurin; 2-CdA or IFN-; clinical trial; multi-agent chemotherapy for MCL; allogeneic HSCT

Midostaurin; 2-CdA or IFN-; clinical trial; multi-agent chemotherapy for MCL; allogeneic HSCT

Midostaurin; 2-CdA or IFN-; clinical trial; multi-agent chemotherapy for MCL; allogeneic HSCT

End

End

End

2-CdA, 2-Chlorodeoxyadenosine; ASM, aggressive systemic mastocytosis; HSCT, hematopoietic stem cell transplantation; ISM, indolent systemic mastocytosis; IFN-, interferon-; MCL, mast cell leukemia; SM, systemic mastocytosis; SM-AHN, systemic mastocytosis with an associated hematologic neoplasm; SSM, smoldering systemic mastocytosis.

2-CdA, 2-Chlorodeoxyadenosine; ASM, aggressive systemic mastocytosis; HSCT, hematopoietic stem cell transplantation; ISM, indolent systemic mastocytosis; IFN-, interferon-; MCL, mast cell leukemia; SM, systemic mastocytosis; SM-AHN, systemic mastocytosis with an associated hematologic neoplasm; SSM, smoldering systemic mastocytosis.

2-CdA, 2-Chlorodeoxyadenosine; ASM, aggressive systemic mastocytosis; HSCT, hematopoietic stem cell transplantation; ISM, indolent systemic mastocytosis; IFN-, interferon-; MCL, mast cell leukemia; SM, systemic mastocytosis; SM-AHN, systemic mastocytosis with an associated hematologic neoplasm; SSM, smoldering systemic mastocytosis.

2-CdA ASM HSCT ISM IFN- MCL SM SM-AHN SSM

Drugs for mediator symptoms

Drugs for mediator symptoms

Drugs for mediator symptoms

SM-AHN

SM-AHN

SM-AHN

Observe

Observe

Observe

Organ damage?

Which disease requires treatment?

Organ damage?

Which disease requires treatment?

Organ damage?

Which disease requires treatment?

AHN-directed treatment

AHN-directed treatment

AHN-directed treatment

Midostaurin; 2-CdA or IFN-; or clinical trial

Midostaurin; 2-CdA or IFN-; or clinical trial

Midostaurin; 2-CdA or IFN-; or clinical trial

Refractory?

Refractory?

Refractory?

2-CdA or IFN- or clinical trial

2-CdA or IFN- or clinical trial

2-CdA or IFN- or clinical trial

ASM/MCL

ASM/MCL

ASM/MCL

SM-AHN

SM-AHN

SM-AHN

ISM or SSM Symptomatic

ISM or SSM Symptomatic

ISM or SSM Symptomatic

ISM Asymptomatic

ISM Asymptomatic

ISM Asymptomatic