Pathogenesis of Systemic Sclerosis Vasculopathy - Flowchart
Pathogenesis of Systemic Sclerosis Vasculopathy - Flowchart Scleroderma (Systemic Sclerosis) Scleroderma (Systemic Sclerosis)
«Flowchart»

Vascular insult (virus, cytotoxic factor, autoantibody, environment)

Vascular insult (virus, cytotoxic factor, autoantibody, environment)

Vascular insult (virus, cytotoxic factor, autoantibody, environment)

Vascular insult

Impaired vasculogenesis

Impaired vasculogenesis

Impaired vasculogenesis

Impaired vasculogenesis

EC injury

EC injury

EC injury EC injury

Defective ECP mobilization

Defective ECP mobilization

Defective ECP mobilization Defective ECP mobilization

Vascular obliteration

Vascular obliteration

Vascular obliteration

Vascular obliteration

Tissue hypoxia

Tissue hypoxia

Tissue hypoxia

Tissue hypoxia

End

End

End

Capillary rarefaction

Capillary rarefaction

Capillary rarefaction

Capillary rarefaction

Vascular wall remodeling
Neointima formation
SMC proliferation
Adventitial fibrosis

Vascular wall remodeling
Neointima formation
SMC proliferation
Adventitial fibrosis

Vascular wall remodeling
Neointima formation
SMC proliferation
Adventitial fibrosis

Vascular wall remodeling


EC apoptosis

EC apoptosis

EC apoptosis EC apoptosis

Endothelium dysfunction
Reduced NO, PGI; increased ET-1, thrombin
Vasoconstriction, impaired relaxation
Ischemia-reperfusion, ROS generation

Endothelium dysfunction
Reduced NO, PGI; increased ET-1, thrombin
Vasoconstriction, impaired relaxation
Ischemia-reperfusion, ROS generation

Endothelium dysfunction


Endothelium dysfunction

Luminal narrowing
Shear stress
Platelet aggregation
Thrombosis

Luminal narrowing
Shear stress
Platelet aggregation
Thrombosis

Luminal narrowing
Shear stress
Platelet aggregation
Thrombosis

Luminal narrowing