Simplified Proposed Pathogenetic Sequence in Sarcoidosis - Flowchart
Simplified Proposed Pathogenetic Sequence in Sarcoidosis - Flowchart Sarcoidosis Sarcoidosis
«Flowchart»

Stimulus (e.g., Ag)

Stimulus (e.g., Ag)

Stimulus (e.g., Ag)

? Genetic predisposition

? Genetic predisposition

? Genetic predisposition

Activated B lymphocytes

Activated B lymphocytes

Activated B lymphocytes

Ab production

Ab production

Ab production

End

End

End

Fibrosis

Fibrosis

Fibrosis

CD4+ lymphocytes

CD4+ lymphocytes

CD4+ lymphocytes

4+

Stimulation of B lymphocytes

Stimulation of B lymphocytes

Stimulation of B lymphocytes

Granuloma formation

Granuloma formation

Granuloma formation

Cytokine-induced recruitment and activation of cells

Cytokine-induced recruitment and activation of cells

Cytokine-induced recruitment and activation of cells

Macrophage

Macrophage

Macrophage

Cytokine-induced recruitment and activation of cells

Cytokine-induced recruitment and activation of cells

Cytokine-induced recruitment and activation of cells

Granuloma formation

Granuloma formation

Granuloma formation

Fibrogenic and growth factors

Fibrogenic and growth factors

Fibrogenic and growth factors