See Table E86 for interpretation of coagulation protein screening tests.
TABLE E86 Clinical Peculiarities of Coagulation Protein Screening Tests
| Long aPTT, Normal or Long PT, No Bleeding | Normal aPTT, PT, with Bleeding | ||
|---|---|---|---|
| Long aPTT only | |||
| Factor XII deficiency | Factor XIII deficiency or inhibitor | ||
| Prekallikrein deficiency | α2-Antiplasmin deficiency or defect | ||
| High-molecular-weight kininogen | Plasminogen activator inhibitor deficiency or defect | ||
| Lupus anticoagulant | α1-Antitrypsin Pittsburgh defect | ||
| Long aPTT and PT | |||
| Dysfibrinogenemia with fibrinopeptide B release | |||
| Lupus anticoagulant |
aPTT, Activated partial thromboplastin time; PT, prothrombin time.
From Hoffman R et al: Hematology: basic principles and practice, ed 5, Philadelphia, 2009, Churchill Livingstone.
Heparin therapy, coagulation factor deficiency (I, II, V, VIII, IX, X, XI, XII), liver disease, vitamin K deficiency, disseminated intravascular coagulation, circulating anticoagulant, warfarin therapy, specific factor inhibition (penicillin [PCN] reaction, rheumatoid arthritis), thrombolytic therapy, nephrotic syndrome